Medicine Information

Sefur

Name: Sefur
Brand: Sefur

Tablet500 mgAntibiotics, Cephalosporins, Second GenerationATC: J01DC02

Generic Name

Cefuroxime 500 mg Tablet

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
sefur 500 mg tablet	৳ 50.00	৳ 350.00

Description

Overview of the medicine

Cefuroxime is a second-generation cephalosporin antibiotic effective against a wide range of bacterial infections.

Uses & Indications

Respiratory tract infections (e.g., bronchitis, pneumonia)

Urinary tract infections

Skin and soft tissue infections

Ear, nose, and throat infections (e.g., otitis media, sinusitis)

Gonorrhea

Dosage

Adults

250-500 mg twice daily depending on the infection severity.

Elderly

Similar to adults, with careful monitoring for renal function.

Renal_impairment

Dosage adjustment is necessary based on creatinine clearance.

How to Take

Orally, preferably with food to enhance absorption and reduce gastrointestinal upset.

Mechanism of Action

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).

Pharmacokinetics

Onset

Within 1-2 hours.

Excretion

Excreted primarily by the kidneys via glomerular filtration and tubular secretion.

Half life

Approximately 1-1.5 hours.

Absorption

Well absorbed orally, bioavailability is enhanced when taken with food.

Metabolism

Not significantly metabolized.

Side Effects

Contraindications

Hypersensitivity to cefuroxime, other cephalosporins, or penicillins.

Drug Interactions

Probenecid

Increases cefuroxime plasma concentrations.

Oral contraceptives

May affect the efficacy of oral contraceptives.

Antacids and H2-receptor antagonists

May decrease bioavailability of cefuroxime.

Storage

Store below 30°C, away from moisture and direct sunlight.

Overdose

Symptoms of overdose may include cerebral irritation leading to convulsions. Treatment is supportive; hemodialysis can be used.

Pregnancy & Lactation

Use during pregnancy and lactation only if clearly needed and under medical supervision. Pregnancy Category B.

Side Effects

Contraindications

Hypersensitivity to cefuroxime, other cephalosporins, or penicillins.

Drug Interactions

Probenecid

Increases cefuroxime plasma concentrations.

Oral contraceptives

May affect the efficacy of oral contraceptives.

Antacids and H2-receptor antagonists

May decrease bioavailability of cefuroxime.

Storage

Store below 30°C, away from moisture and direct sunlight.

Overdose

Symptoms of overdose may include cerebral irritation leading to convulsions. Treatment is supportive; hemodialysis can be used.

Pregnancy & Lactation

Use during pregnancy and lactation only if clearly needed and under medical supervision. Pregnancy Category B.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per blister30 tablets per box

Shelf Life

36 months

Availability

Pharmacies, Hospitals

Approval Status

Approved by FDA/DGDA

Patent Status

Generic available, patent expired

WHO Essential Medicine

Yes

Clinical Trials

Extensively studied in clinical trials for its efficacy and safety in various bacterial infections.

Lab Monitoring

Periodic monitoring of renal function during prolonged therapy.
Liver function tests may be considered.

Doctor Notes

Advise patients to complete the full course of antibiotics to prevent resistance.
Monitor for signs of C. difficile infection if severe or persistent diarrhea occurs.

Patient Guidelines

Complete the entire course of medication even if symptoms improve.
Take with food to reduce stomach upset.
Report any severe or persistent diarrhea to your doctor.

Missed Dose Advice

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.