Sinaceph
Generic Name
Cephalexin
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sinaceph 250 mg capsule | ৳ 6.80 | ৳ 34.00 |
Description
Overview of the medicine
Sinaceph 250 mg Capsule is an antibiotic used to treat various bacterial infections like respiratory tract infections, urinary tract infections, skin and soft tissue infections, and bone and joint infections.
Uses & Indications
Dosage
Adults
250 mg to 500 mg every 6 hours, or 500 mg every 12 hours, depending on the severity and type of infection. Maximum 4 g/day.
Elderly
Similar to adult dosage, but dose adjustment may be necessary in patients with impaired renal function.
Renal_impairment
Dosage adjustment required based on creatinine clearance. e.g., CrCl 30-50 mL/min: 250 mg every 8-12 hours; CrCl 10-29 mL/min: 250 mg every 12-24 hours; CrCl <10 mL/min: 250 mg every 24-48 hours.
How to Take
Oral administration. Can be taken with or without food. To minimize gastrointestinal upset, it may be taken with food.
Mechanism of Action
Cephalexin is a first-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Rapid onset, peak plasma concentrations typically achieved within 1 hour.
Excretion
Primarily excreted unchanged in the urine by glomerular filtration and tubular secretion.
Half life
Approximately 0.5 to 1.2 hours in individuals with normal renal function.
Absorption
Well absorbed from the gastrointestinal tract (about 90% orally).
Metabolism
Minimal hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- •Hypersensitivity to cephalexin or other cephalosporins.
- •History of severe hypersensitivity reactions to penicillin.
Drug Interactions
Metformin
May increase plasma concentrations of metformin, requiring dose adjustment.
Probenecid
Increases and prolongs plasma concentrations of cephalexin.
Oral anticoagulants (e.g., Warfarin)
May increase the anticoagulant effect, requiring INR monitoring.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, epigastric distress, diarrhea, and hematuria. Management is supportive, including gastric lavage or activated charcoal. Hemodialysis may be useful in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe, but use with caution and only if clearly needed. Excreted in low concentrations in breast milk; generally considered compatible with breastfeeding, but monitor infant for adverse effects like diarrhea or thrush.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Expired / Generic
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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