Medicine Information

Aceflex

Name: Aceflex
Brand: Aceflex
Rating: 4.5 (117 reviews)

Tablet100 mgNon-Steroidal Anti-Inflammatory Drug (NSAID)ATC: M01AB16

Generic Name

Aceclofenac

Manufacturer

Healthcare Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
aceflex 100 mg tablet	৳ 5.00	৳ 50.00

Description

Overview of the medicine

Aceflex 100 mg Tablet contains Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID) used for symptomatic treatment of pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.

Uses & Indications

Osteoarthritis

Rheumatoid Arthritis

Ankylosing Spondylitis

Pain and inflammation in musculoskeletal disorders

Dental pain and post-operative pain

Dosage

Adults

The recommended dose is 100 mg twice daily, preferably with or after food.

Elderly

The usual adult dosage can be given, but caution is advised. A lower starting dose may be considered.

Renal_impairment

No evidence that the dose of Aceclofenac needs to be modified in patients with mild renal impairment, but caution is advised. Should be avoided in severe renal impairment.

How to Take

Take Aceflex 100 mg Tablet orally, preferably with or after food to minimize gastrointestinal discomfort. Swallow the tablet whole with water; do not chew or crush.

Mechanism of Action

Aceclofenac exerts its anti-inflammatory and analgesic effects primarily by inhibiting the enzyme cyclo-oxygenase (COX), leading to decreased prostaglandin synthesis. It shows some selectivity for COX-2 over COX-1, which may contribute to a better gastrointestinal tolerability profile.

Pharmacokinetics

Onset

Analgesic effect usually within 30-60 minutes.

Excretion

Approximately two-thirds of the administered dose is excreted in the urine, mainly as hydroxylated metabolites, and one-third in the faeces.

Half life

Approximately 4-4.3 hours.

Absorption

Rapid and complete absorption after oral administration, with peak plasma concentrations reached in 1.25 to 3 hours.

Metabolism

Extensive metabolism in the liver, primarily via CYP2C9, to 4'-hydroxyaceclofenac and other metabolites.

Side Effects

Contraindications

Hypersensitivity to Aceclofenac or any components of the tablet.
Patients with active gastrointestinal ulceration, bleeding or perforation.
Patients who have experienced asthma, acute rhinitis, angioedema, or urticaria after taking aspirin or other NSAIDs.
Severe heart failure, hepatic failure, or renal failure.
Third trimester of pregnancy.

Drug Interactions

SSRIs

Increased risk of gastrointestinal bleeding.

Lithium

Increased plasma lithium levels.

Warfarin

Increased risk of bleeding.

Methotrexate

Increased plasma methotrexate levels and toxicity.

Corticosteroids

Increased risk of gastrointestinal ulceration or bleeding.

Cyclosporine, Tacrolimus

Increased risk of nephrotoxicity.

Diuretics and ACE Inhibitors

Reduced hypotensive effect and increased risk of renal impairment.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include nausea, vomiting, epigastric pain, gastrointestinal bleeding, diarrhea, dizziness, disorientation, excitation, coma, drowsiness, tinnitus, and convulsions. In cases of significant poisoning, acute renal failure and liver damage are possible. Management involves symptomatic and supportive treatment, including gastric lavage, activated charcoal, and monitoring of vital signs and laboratory parameters.

Pregnancy & Lactation

Pregnancy Category C (first and second trimester), Category D (third trimester). Aceclofenac should be avoided during the third trimester of pregnancy due to the risk of premature closure of the ductus arteriosus and potential renal dysfunction in the fetus. Use with caution in the first and second trimesters only if the potential benefit justifies the potential risk to the fetus. Not recommended during lactation as Aceclofenac is excreted in breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 x 10 tablets (100 tablets in a box)

Shelf Life

Usually 2-3 years from the date of manufacture.

Availability

Pharmacies, Hospitals

Approval Status

Approved (DGDA, Bangladesh)

Patent Status

Off-patent

Clinical Trials

Aceclofenac has undergone extensive clinical trials demonstrating its efficacy and safety in various inflammatory and painful conditions. Ongoing post-marketing surveillance continues to monitor its effects.

Lab Monitoring

Renal function (creatinine, BUN) in long-term therapy or in patients with pre-existing renal impairment.
Liver function tests (ALT, AST) periodically, especially in long-term use.
Complete Blood Count (CBC) for potential anemia or other hematological effects.
Stool occult blood test for gastrointestinal bleeding.

Doctor Notes

Prescribe the lowest effective dose for the shortest possible duration to minimize adverse effects.
Assess cardiovascular and gastrointestinal risk factors before initiating therapy, especially in elderly patients.
Monitor renal and hepatic function during long-term treatment.

Patient Guidelines

Take Aceflex 100 mg tablet exactly as prescribed by your doctor.
Always take this medicine with or after food to reduce stomach upset.
Do not exceed the recommended dose or duration of treatment.
Report any signs of stomach bleeding (e.g., black or tarry stools, vomiting blood) or allergic reactions immediately.
Avoid alcohol while taking this medication as it may increase the risk of stomach problems.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.