Medicine Information

Afix

Name: Afix
Brand: Afix
Rating: 4.5 (117 reviews)

Capsule400 mg3rd Generation CephalosporinsATC: J01DD08

Generic Name

Cefixime 400 mg Capsule

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
afix 400 mg capsule	৳ 60.00	৳ 420.00

Description

Overview of the medicine

Cefixime is an oral third-generation cephalosporin antibiotic used to treat various bacterial infections.

Uses & Indications

Urinary Tract Infections (UTIs)

Otitis Media

Pharyngitis and Tonsillitis

Acute Bronchitis and exacerbations of Chronic Bronchitis

Uncomplicated Gonorrhea

Dosage

Adults

400 mg once daily or 200 mg every 12 hours, typically for 7-14 days depending on infection.

Elderly

No specific dose adjustment for elderly unless renal function is impaired.

Renal_impairment

Dose adjustment required for creatinine clearance < 60 mL/min. For CrCl 21-60 mL/min, 300 mg daily; for CrCl < 20 mL/min, 200 mg daily.

How to Take

Afix 400 mg capsule should be taken orally, with or without food. It is recommended to complete the full prescribed course.

Mechanism of Action

Cefixime works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death.

Pharmacokinetics

Onset

Varies by infection type; generally within hours to days.

Excretion

Primarily excreted unchanged in urine and bile.

Half life

3-4 hours (average).

Absorption

Approximately 40-50% orally absorbed. Absorption may be slightly increased with food.

Metabolism

Minimal hepatic metabolism; no active metabolites identified.

Side Effects

Contraindications

Known hypersensitivity to cefixime, other cephalosporins, or penicillins.
History of severe allergic reactions to penicillin (due to potential cross-reactivity).

Drug Interactions

Probenecid

Increases cefixime plasma concentrations by decreasing renal excretion.

Carbamazepine

Elevated carbamazepine levels have been reported with concomitant use (rare).

Warfarin and other anticoagulants

May increase prothrombin time (INR), requiring close monitoring and dose adjustment of anticoagulants.

Storage

Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.

Overdose

In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be supportive.

Pregnancy & Lactation

Pregnancy Category B. Cefixime is excreted in small amounts in breast milk; generally considered compatible with breastfeeding, but caution is advised.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 x 7 capsules (blister pack)1 x 5 capsules (blister pack)

Shelf Life

Typically 24 to 36 months from the date of manufacture.

Availability

Pharmacies, Hospitals

Approval Status

Approved by regulatory authorities (e.g., DGDA, FDA)

Patent Status

Off-patent (Generic available)

WHO Essential Medicine

Yes

Clinical Trials

Cefixime has undergone numerous clinical trials demonstrating its efficacy and safety for various bacterial infections.

Lab Monitoring

Renal function in patients with pre-existing renal impairment or during prolonged therapy.
Complete blood count (CBC) during prolonged treatment.
Liver function tests (LFTs) if signs of liver dysfunction occur.

Doctor Notes

Always inquire about penicillin allergy history before prescribing due to potential cross-reactivity with cephalosporins.
Adjust dosage in patients with renal impairment to prevent accumulation and potential toxicity.
Monitor for signs of Clostridium difficile-associated diarrhea if severe diarrhea develops during or after treatment.

Patient Guidelines

Take the medicine for the full prescribed duration, even if symptoms improve.
Do not share this medication with others, even if they have similar symptoms.
Report any severe or persistent side effects to your doctor.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.