Medicine Information

Aparkin

Name: Aparkin
Brand: Aparkin
Rating: 4.5 (117 reviews)

Capsule200 mgNootropics & Neurotonics / Cerebral ActivatorsATC: N06BX03

Generic Name

Piracetam

Manufacturer

Renata Limited

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
aparkin 200 mg capsule	৳ 18.00	৳ 144.00

Description

Overview of the medicine

Piracetam is a nootropic agent that improves cognitive function, memory, and learning by enhancing neuronal activity. It is used to treat conditions associated with cognitive decline and certain neurological disorders.

Uses & Indications

Cognitive impairment (e.g., age-related memory decline, attention deficits)

Cortical myoclonus (as an adjunct therapy)

Vertigo and associated balance disorders of central and peripheral origin

Adjunct in dyslexia in children, combined with appropriate therapeutic measures

Post-stroke aphasia (for recovery of speech function)

Dosage

Adults

For cognitive impairment: 2.4 g to 4.8 g daily, divided into 2-3 doses. For cortical myoclonus: Initially 7.2 g daily, increasing by 4.8 g every 3-4 days up to a maximum of 24 g daily, divided into 2-3 doses. For vertigo: 2.4 g to 4.8 g daily, divided into 2-3 doses.

Elderly

No specific dose adjustment needed unless renal impairment is present. It is recommended to monitor renal function in elderly patients and adjust dosage accordingly.

Renal_impairment

Dosage adjustment required based on creatinine clearance (CrCl). CrCl 50-79 mL/min: 2/3 of usual dose, 2-3 times daily. CrCl 30-49 mL/min: 1/3 of usual dose, 2 times daily. CrCl < 30 mL/min: Contraindicated or significantly reduced dose.

How to Take

Swallow capsules whole with water, with or without food. For cortical myoclonus, it is crucial to take doses regularly at spaced intervals.

Mechanism of Action

Piracetam enhances neuroplasticity, facilitates interhemispheric transfer of information, and improves microcirculation without causing vasodilation. It may restore normal membrane fluidity and protect neurons from hypoxic damage.

Pharmacokinetics

Onset

Generally within 30-60 minutes.

Excretion

Excreted unchanged primarily via the kidneys. Approximately 80-100% of the administered dose is excreted in urine within 24-48 hours.

Half life

Approximately 4-5 hours in plasma; 6-8 hours in cerebrospinal fluid.

Absorption

Rapid and complete absorption after oral administration. Bioavailability is nearly 100%. Peak plasma concentrations are reached within approximately 1 hour.

Metabolism

Not metabolized in the human body. Piracetam is chemically stable and does not interact with liver enzymes.

Side Effects

Contraindications

Hypersensitivity to piracetam or other pyrrolidone derivatives or any excipients of the formulation
Severe renal impairment (creatinine clearance < 20 mL/min)
Cerebral hemorrhage
Huntington's chorea (due to potential for exacerbation)

Drug Interactions

Warfarin

Concomitant use with warfarin may prolong prothrombin time; INR should be closely monitored and warfarin dose adjusted if necessary.

Thyroid hormones

Possible confusion, irritability, and sleep disturbance have been reported when piracetam was used concomitantly with thyroid extracts (T3 + T4).

Anticoagulants/Antiplatelets

May potentiate the effects of these medications; caution advised.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

In case of acute overdose, management is symptomatic and supportive. Gastric lavage or induction of emesis may be considered immediately after ingestion. Hemodialysis is an effective method for piracetam removal.

Pregnancy & Lactation

Piracetam is not recommended during pregnancy and lactation due to insufficient data and animal studies showing placental transfer. Use only if clearly needed and benefits outweigh potential risks.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules per strip30 capsules per box (3 strips of 10 capsules)

Shelf Life

Typically 2-3 years from the manufacturing date, when stored under recommended conditions.

Availability

Pharmacies and Hospitals

Approval Status

Approved

Patent Status

Off-patent

Clinical Trials

Piracetam has been extensively studied for various indications. While some studies have shown positive results in improving cognitive function and treating conditions like cortical myoclonus, others have yielded inconclusive or mixed findings, especially for broader cognitive enhancement.

Lab Monitoring

No routine lab monitoring generally required. Renal function (e.g., serum creatinine, creatinine clearance) should be monitored in patients with renal impairment, especially in elderly individuals.
For patients on concomitant warfarin therapy, INR should be monitored closely.

Doctor Notes

Advise patients on gradual withdrawal of piracetam, especially in cortical myoclonus, to avoid the risk of sudden relapse or withdrawal symptoms. Doses should be decreased by 1.2 g-2.4 g every two days.
Consider assessing renal function, particularly in elderly patients or those with pre-existing renal impairment, before initiating and during piracetam therapy to ensure appropriate dosage.
Caution patients about potential interactions with anticoagulants and thyroid hormones. Advise them to report any unusual bleeding or changes in mood/sleep.

Patient Guidelines

Take Aparkin exactly as prescribed by your doctor. Do not change the dose or stop the medication without consulting your doctor.
If you are taking Aparkin for cortical myoclonus, do not stop abruptly as it may lead to sudden relapse or withdrawal symptoms.
Inform your doctor or pharmacist about all other medications, supplements, and herbal products you are taking to avoid potential interactions.
If you experience any unusual side effects, report them to your doctor promptly.

Missed Dose Advice

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose to make up for a missed one.

Driving Precautions

Aparkin may cause drowsiness, dizziness, or nervousness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.

Lifestyle Advice

Maintain a healthy and balanced diet, get regular exercise, and ensure adequate sleep to support overall cognitive health.
Avoid excessive alcohol consumption, as it can impair cognitive function and may interact with the medication.