Arthrocare
Generic Name
Diacerein
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
arthrocare 250 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Arthrocare 250 mg Tablet contains Diacerein, which is used for the treatment of osteoarthritis. It helps to reduce pain and inflammation and slows down cartilage degradation.
Uses & Indications
Dosage
Adults
Initially, 50 mg once daily for 2-4 weeks, then 50 mg twice daily (with breakfast and dinner).
Elderly
Similar to adult dosage, but consider renal function.
Renal_impairment
In severe renal impairment (creatinine clearance < 30 mL/min), the dosage should be reduced.
How to Take
Take orally with food to improve absorption and reduce gastrointestinal side effects.
Mechanism of Action
Diacerein acts by inhibiting the synthesis and activity of interleukin-1 beta (IL-1β), a key cytokine involved in cartilage degradation and inflammation in osteoarthritis.
Pharmacokinetics
Onset
Clinical effects typically appear after 2-4 weeks of treatment.
Excretion
Primarily excreted via the urine as Rhein and its metabolites.
Half life
The plasma half-life of Rhein is approximately 4-5 hours.
Absorption
Well absorbed orally and rapidly deacetylated into its active metabolite, Rhein. Bioavailability is approximately 35-56%.
Metabolism
Mainly metabolized in the liver to Rhein, Rhein-glucuronide, and Rhein-sulfate.
Side Effects
Contraindications
- Hypersensitivity to Diacerein or any component of the formulation
- Severe liver disease
- Inflammatory bowel disease
- History of chronic diarrhea
Drug Interactions
Antacids
Concurrent use of antacids may decrease the absorption of Diacerein. Take Diacerein at least 2 hours before or after antacids.
Laxatives
Diacerein itself can cause diarrhea. Concomitant use with laxatives may increase the risk of diarrhea.
Iron salts, Calcium salts
May reduce absorption; separate administration by at least 2 hours.
Storage
Store in a cool, dry place below 25°C, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic treatment and supportive measures should be implemented. Gastric lavage may be considered.
Pregnancy & Lactation
Not recommended during pregnancy and lactation due to insufficient safety data. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA/FDA for osteoarthritis treatment
Patent Status
Generic available
Clinical Trials
Several clinical trials have demonstrated the efficacy and safety of Diacerein in the treatment of osteoarthritis, showing beneficial effects on pain, function, and reduction in joint space narrowing.
Lab Monitoring
- Liver function tests (before initiation and periodically during treatment, especially in patients with pre-existing liver conditions)
- Renal function monitoring (in patients with renal impairment)
Doctor Notes
- Monitor patient's liver function tests periodically, especially before starting treatment and during the first 6 months.
- Advise patients about potential gastrointestinal side effects, particularly diarrhea, and manage accordingly.
- Not recommended for patients with existing inflammatory bowel disease or severe liver impairment.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Always take it with food.
- Report any severe diarrhea or abdominal pain to your doctor.
- Do not stop taking the medicine without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine is generally not known to impair the ability to drive or operate machinery. However, if you experience dizziness or fatigue, avoid such activities.
Lifestyle Advice
- Maintain a healthy weight to reduce stress on joints.
- Engage in regular, low-impact exercise suitable for osteoarthritis.
- Follow a balanced diet.
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Global Brand Names
International brand names for this medicine
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