Medicine Information

Avlotrin

Name: Avlotrin
Brand: Avlotrin
Rating: 4.5 (117 reviews)

Suspension200 mgAnthelmintic, Anti-wormATC: P02CA03

Generic Name

Albendazole

Manufacturer

Renata Limited

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
avlotrin 200 mg suspension	৳ 22.21	N/A

Description

Overview of the medicine

Avlotrin 200 mg Suspension contains Albendazole, a broad-spectrum anthelmintic used to treat various types of parasitic worm infections in the gut and other tissues.

Uses & Indications

Ascariasis (roundworm)

Ancylostomiasis (hookworm)

Enterobiasis (pinworm/threadworm)

Trichuriasis (whipworm)

Strongyloidiasis (threadworm)

Giardiasis (in children)

Cystic echinococcosis

Neurocysticercosis

Dosage

Adults

Typical intestinal worm infections: 400 mg (20 mL suspension) as a single dose. For Strongyloidiasis or Taeniasis: 400 mg once daily for 3 days. Doses vary significantly for tissue infections (e.g., neurocysticercosis, echinococcosis) requiring prolonged treatment.

Elderly

No specific dose adjustment is generally required for elderly patients, but caution is advised in those with hepatic or renal impairment.

Renal_impairment

No significant dosage adjustment is usually required as renal excretion of the active metabolite is minimal. However, caution is advised.

Hepatic_impairment

Use with caution in patients with hepatic impairment, as albendazole is extensively metabolized in the liver. Liver function tests should be monitored.

How to Take

Administer orally. For best absorption, it should be taken with food, especially a fatty meal.

Mechanism of Action

Albendazole selectively binds to beta-tubulin, inhibiting tubulin polymerization, which leads to disruption of the parasite's metabolism and ultimately its death.

Pharmacokinetics

Onset

Onset of action is variable, depending on the type and location of the helminthic infection.

Excretion

Primarily excreted in the bile as metabolites; a small amount is excreted in the urine.

Half life

Parent drug: short; Active metabolite (Albendazole sulfoxide): approximately 8-12 hours.

Absorption

Poorly absorbed from the gastrointestinal tract. Absorption is significantly increased when taken with a fatty meal.

Metabolism

Rapidly and extensively metabolized in the liver to the active metabolite, albendazole sulfoxide, and then to inactive sulfone metabolites.

Side Effects

Contraindications

Hypersensitivity to albendazole or any component of the formulation.
Pregnancy, especially during the first trimester (due to potential embryotoxicity/teratogenicity).

Drug Interactions

Cimetidine

Increases plasma concentrations of albendazole sulfoxide.

Praziquantel

Increases plasma concentrations of albendazole sulfoxide.

Theophylline

Albendazole may decrease theophylline clearance; monitor theophylline levels.

Dexamethasone

Increases plasma concentrations of albendazole sulfoxide.

Storage

Store below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote.

Pregnancy & Lactation

Pregnancy Category C/D (depending on exposure). Avoid in the first trimester. Use only if potential benefit outweighs risk. Caution should be exercised when administering to nursing mothers as it is unknown if albendazole or its metabolites are excreted in human milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 mL bottle20 mL bottle

Shelf Life

Typically 2-3 years from the date of manufacture, specific details are on the packaging.

Availability

Available in pharmacies, hospitals and clinics

Approval Status

Approved by major regulatory bodies (e.g., FDA, DGDA)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Albendazole has undergone extensive clinical trials demonstrating its efficacy and safety in various helminthic infections. Ongoing research explores its use in combination therapies and other parasitic diseases.

Lab Monitoring

Liver function tests (LFTs) should be monitored before and during prolonged therapy, especially with higher doses.
Complete Blood Count (CBC) for prolonged therapy, especially for signs of myelosuppression.

Doctor Notes

For prolonged courses or high doses, monitor LFTs and CBC.
Advise patients about taking the medicine with food to improve absorption.
Emphasize the importance of hygiene to prevent reinfection.
Counsel pregnant or breastfeeding women on risks versus benefits.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Swallow the suspension with food for better absorption.
Complete the full course of treatment, even if you feel better, to ensure all worms are eliminated.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Albendazole may cause dizziness in some individuals. If you experience dizziness, avoid driving or operating machinery until you know how the medicine affects you.

Lifestyle Advice

Maintain good personal hygiene, including frequent handwashing, to prevent re-infection.
Ensure proper sanitation and avoid consuming contaminated food or water.