Medicine Information

Azmasol

Name: Azmasol
Brand: Azmasol
Rating: 4.5 (117 reviews)

Inhaler (Metered-Dose Inhaler - MDI)100 mcgBronchodilator, Beta-2 Adrenoceptor AgonistATC: R03AC02

Generic Name

Salbutamol (Albuterol)

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
azmasol 100 mcg inhaler	৳ 250.00	N/A

Description

Overview of the medicine

Azmasol 100 mcg Inhaler contains Salbutamol, a short-acting beta-2 agonist (SABA) used for the rapid relief of symptoms of asthma and chronic obstructive pulmonary disease (COPD) such as wheezing, shortness of breath, and chest tightness.

Uses & Indications

Relief of bronchospasm in all types of bronchial asthma.

Relief of bronchospasm in chronic obstructive pulmonary disease (COPD).

Prevention of exercise-induced bronchospasm.

Dosage

Adults

For relief of acute asthma symptoms: 1 or 2 puffs (100 or 200 mcg) as needed. For prevention of exercise-induced bronchospasm: 2 puffs 15-30 minutes before exercise. Do not exceed 8 puffs in 24 hours.

Elderly

Similar to adult dosage, but individual response should be monitored. Start with the lowest effective dose.

Renal_impairment

No specific dosage adjustment is generally required for mild to moderate renal impairment, but caution is advised in severe cases.

How to Take

For oral inhalation only. Shake the inhaler well before each use. Inhale slowly and deeply through the mouthpiece while pressing the canister. Hold your breath for about 10 seconds, then exhale slowly. Rinse your mouth with water after use to reduce the risk of oral thrush.

Mechanism of Action

Salbutamol selectively stimulates beta-2 adrenergic receptors in bronchial smooth muscle, leading to bronchodilation. This relaxes the airways, allowing easier breathing.

Pharmacokinetics

Onset

Bronchodilation typically occurs within 5-15 minutes.

Excretion

Primarily excreted in the urine as unchanged drug (about 60%) and its inactive sulfate metabolite.

Half life

Plasma half-life is 4-6 hours.

Absorption

Rapidly absorbed from the lungs following inhalation, with systemic bioavailability of 10-20% of the inhaled dose.

Metabolism

Partially metabolized in the liver to an inactive sulfate conjugate.

Side Effects

Contraindications

Hypersensitivity to salbutamol or any of the excipients.

Drug Interactions

Digoxin

Increased risk of digoxin toxicity if hypokalemia occurs.

Diuretics

May increase the risk of hypokalemia with high doses of salbutamol.

MAOIs and TCAs

Concurrent use may potentiate the vascular effects of salbutamol, increasing the risk of adverse cardiovascular events.

Beta-blockers (non-selective)

May reduce the bronchodilatory effect of salbutamol and can precipitate severe bronchospasm.

Storage

Store below 30°C. Protect from direct sunlight and frost. Do not puncture, burn or throw into fire even when empty. Keep out of reach of children.

Overdose

Symptoms of overdose include tachycardia, tremors, headache, and hypokalemia. Management is supportive, and in severe cases, cautious use of a cardioselective beta-blocker may be considered.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Salbutamol may be excreted in breast milk; use with caution during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 Inhaler (200 actuations)

Shelf Life

Typically 2-3 years from the date of manufacture. Check the expiry date on the packaging.

Availability

Available in pharmacies and hospitals.

Approval Status

Approved by regulatory bodies worldwide for general use.

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Salbutamol has been extensively studied in numerous clinical trials establishing its efficacy and safety for the treatment of asthma and COPD. These studies support its use as a first-line rescue medication.

Lab Monitoring

Monitor serum potassium levels, especially in patients receiving high doses or concomitant therapy with diuretics or corticosteroids, due to the risk of hypokalemia.

Doctor Notes

Emphasize proper inhaler technique to ensure optimal drug delivery and patient education on when and how to use their rescue inhaler.
Monitor for overuse; increasing reliance on a SABA often indicates poorly controlled asthma, necessitating a review of maintenance therapy.
Always consider prescribing an inhaled corticosteroid (ICS) for patients with persistent asthma, as SABAs are only for symptomatic relief.

Patient Guidelines

Ensure proper inhaler technique for effective delivery of the medicine.
Rinse your mouth with water after each use to prevent oral candidiasis.
Do not exceed the prescribed dose without consulting your doctor.
Seek medical attention immediately if your breathing worsens or if you need to use your inhaler more often than usual.

Missed Dose Advice

Azmasol Inhaler is used as needed. If you forget to use it when symptoms appear, take a dose as soon as you remember. Do not take a double dose to make up for a missed one.

Driving Precautions

Azmasol usually does not affect the ability to drive or operate machinery. However, if you experience side effects like tremor or dizziness, avoid these activities.