Betadine
Generic Name
Povidone-iodine 10% w/v Solution
Manufacturer
Mundipharma
Country
Singapore
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| betadine 10 w solution | ৳ 120.00 | N/A |
Description
Overview of the medicine
Povidone-iodine 10% w/v solution is an antiseptic used for disinfection of skin, mucous membranes, and wounds. It helps prevent infections caused by bacteria, viruses, fungi, and protozoa.
Uses & Indications
Dosage
Adults
Apply undiluted to the affected area or as directed by a healthcare professional. Can be diluted for specific uses (e.g., gargle, douche) as advised.
Elderly
No specific dosage adjustment required.
Renal_impairment
Use with caution in patients with severe renal impairment due to potential for iodine absorption, especially with prolonged use or large areas.
How to Take
For external use only. Apply topically to the skin or mucous membranes. Can be used as a gargle, mouthwash, or vaginal douche when appropriately diluted.
Mechanism of Action
Povidone-iodine releases iodine, which rapidly penetrates microbial cells and oxidizes proteins, nucleotides, and fatty acids, leading to cell death. It is effective against bacteria, viruses, fungi, and protozoa.
Pharmacokinetics
Onset
Rapid, within seconds.
Excretion
Primarily via urine when absorbed systemically.
Half life
Iodine's systemic half-life is variable but typically several days to weeks when absorbed.
Absorption
Minimal systemic absorption through intact skin. Increased absorption can occur from large wound surfaces or mucous membranes.
Metabolism
Iodine is not metabolized; it's released from the povidone complex.
Side Effects
Contraindications
- Known hypersensitivity to iodine or povidone
- Thyroid disorders (e.g., hyperthyroidism, goiter)
- Prior to and after radioiodine therapy
- Newborns and very young infants (risk of systemic iodine absorption)
Drug Interactions
Lithium
Concomitant use with systemic lithium therapy may lead to additive hypothyroid effects.
Hydrogen peroxide
Concurrent use may reduce the efficacy of both.
Silver sulfadiazine
May reduce antiseptic efficacy.
Storage
Store in a cool, dry place, below 30°C. Protect from light. Keep out of reach of children.
Overdose
Systemic absorption of large amounts of iodine can lead to thyroid dysfunction (hyper- or hypothyroidism), metabolic acidosis, and renal impairment. Management is supportive.
Pregnancy & Lactation
Use with caution and only if clearly needed. Excessive iodine absorption could affect fetal/infant thyroid function.
Side Effects
Contraindications
- Known hypersensitivity to iodine or povidone
- Thyroid disorders (e.g., hyperthyroidism, goiter)
- Prior to and after radioiodine therapy
- Newborns and very young infants (risk of systemic iodine absorption)
Drug Interactions
Lithium
Concomitant use with systemic lithium therapy may lead to additive hypothyroid effects.
Hydrogen peroxide
Concurrent use may reduce the efficacy of both.
Silver sulfadiazine
May reduce antiseptic efficacy.
Storage
Store in a cool, dry place, below 30°C. Protect from light. Keep out of reach of children.
Overdose
Systemic absorption of large amounts of iodine can lead to thyroid dysfunction (hyper- or hypothyroidism), metabolic acidosis, and renal impairment. Management is supportive.
Pregnancy & Lactation
Use with caution and only if clearly needed. Excessive iodine absorption could affect fetal/infant thyroid function.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Povidone-iodine has been extensively studied for decades. Numerous clinical trials confirm its efficacy as a broad-spectrum antiseptic for skin preparation, wound care, and infection prevention.
Lab Monitoring
- Thyroid function tests (if large areas are treated for prolonged periods or in susceptible individuals)
- Renal function (in cases of significant systemic absorption)
Doctor Notes
- Ensure patient has no history of thyroid disorders before prolonged use.
- Advise patients on proper dilution if used for gargling or douching.
- Monitor for signs of allergic reactions or skin irritation.
Patient Guidelines
- For external use only. Do not swallow.
- Avoid contact with eyes. If contact occurs, rinse thoroughly with water.
- Do not use on large areas of broken skin or for prolonged periods without medical advice.
- Discontinue use if irritation or rash develops.
Missed Dose Advice
As an OTC topical antiseptic, 'missed dose' isn't strictly applicable. Apply when needed for disinfection.
Driving Precautions
Not applicable for topical antiseptic. Does not affect ability to drive or operate machinery.
Lifestyle Advice
- Maintain good hygiene to prevent infection.
- Keep wounds clean and covered.
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