Betadine
Generic Name
Povidone-iodine
Manufacturer
Mundipharma
Country
Various
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
betadine 75 w surgical scrub | ৳ 150.00 | N/A |
Description
Overview of the medicine
Betadine 7.5% w/v Surgical Scrub is an antiseptic solution used for surgical hand scrubbing and pre-operative skin preparation of patients to reduce the risk of infection.
Uses & Indications
Dosage
Adults
For surgical hand scrub: Wet hands and forearms, apply 5 mL of scrub, spread thoroughly and scrub for 5 minutes. Rinse thoroughly. Apply another 5 mL and scrub for 2.5 minutes, rinse thoroughly. For pre-operative skin prep: Apply undiluted to surgical site, scrub for 2 minutes, rinse off with water and sterile towel.
Elderly
No specific dosage adjustment required.
Renal_impairment
Use with caution in patients with severe renal impairment due to potential for iodine absorption.
How to Take
For external use only. Apply to wet skin, scrub thoroughly, and rinse. Avoid contact with eyes.
Mechanism of Action
Povidone-iodine works by releasing free iodine, which rapidly penetrates microbial cells, oxidizes proteins, nucleotides, and fatty acids, leading to cell death. It has a broad spectrum of antimicrobial activity against bacteria, fungi, viruses, protozoa, and spores.
Pharmacokinetics
Onset
Rapid, within seconds to minutes of application.
Excretion
Absorbed iodide is excreted primarily via the kidneys.
Half life
Not applicable for topical use, as systemic absorption is minimal.
Absorption
Minimal systemic absorption through intact skin. Absorption may increase with application to large areas of broken skin or mucous membranes.
Metabolism
Absorbed iodine is metabolized in the liver, similar to naturally occurring iodide.
Side Effects
Contraindications
- Known hypersensitivity to iodine or povidone
- History of thyroid disorders (e.g., hyperthyroidism, goitre)
- In newborns and infants, especially premature babies, due to risk of iodine-induced hypothyroidism
- Before and after radioiodine therapy
Drug Interactions
Hydrogen peroxide
Concurrent use may reduce efficacy of both due to inactivation.
Silver sulfadiazine
May reduce efficacy of povidone-iodine and risk of systemic iodine absorption.
Storage
Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children.
Overdose
Accidental ingestion or extensive topical application to large, broken skin areas may lead to systemic iodine absorption, resulting in symptoms such as metabolic acidosis, renal failure, and thyroid dysfunction (hyperthyroidism or hypothyroidism). Treatment is symptomatic and supportive, including gastric lavage if ingested and monitoring of thyroid function and electrolyte balance.
Pregnancy & Lactation
Povidone-iodine should be used during pregnancy and lactation only if clearly indicated and with caution, as absorbed iodine can cross the placenta and be excreted in breast milk, potentially affecting fetal/infant thyroid function. Short-term, limited application is generally considered low risk.
Side Effects
Contraindications
- Known hypersensitivity to iodine or povidone
- History of thyroid disorders (e.g., hyperthyroidism, goitre)
- In newborns and infants, especially premature babies, due to risk of iodine-induced hypothyroidism
- Before and after radioiodine therapy
Drug Interactions
Hydrogen peroxide
Concurrent use may reduce efficacy of both due to inactivation.
Silver sulfadiazine
May reduce efficacy of povidone-iodine and risk of systemic iodine absorption.
Storage
Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children.
Overdose
Accidental ingestion or extensive topical application to large, broken skin areas may lead to systemic iodine absorption, resulting in symptoms such as metabolic acidosis, renal failure, and thyroid dysfunction (hyperthyroidism or hypothyroidism). Treatment is symptomatic and supportive, including gastric lavage if ingested and monitoring of thyroid function and electrolyte balance.
Pregnancy & Lactation
Povidone-iodine should be used during pregnancy and lactation only if clearly indicated and with caution, as absorbed iodine can cross the placenta and be excreted in breast milk, potentially affecting fetal/infant thyroid function. Short-term, limited application is generally considered low risk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date, refer to product label.
Availability
Pharmacies, Hospitals, Medical Supply Stores
Approval Status
Approved
Patent Status
Expired
Clinical Trials
Extensively studied and widely used antiseptic. Clinical trials often focus on specific surgical applications, comparison with other antiseptics, or efficacy in new settings. Data supports its broad-spectrum antimicrobial activity and efficacy in preventing surgical site infections.
Lab Monitoring
- Thyroid function tests (TSH, T3, T4) in patients with prolonged or extensive use, or in those at risk of thyroid dysfunction.
Doctor Notes
- Ensure patient does not have iodine allergy before use.
- Monitor thyroid function in patients with extensive or prolonged use, especially in neonates or those with pre-existing thyroid conditions.
- Avoid pooling under the patient during surgery to prevent skin irritation and potential absorption.
Patient Guidelines
- For external use only.
- Avoid contact with eyes, ears, nose, and mouth.
- Do not use on large areas of broken skin or for prolonged periods without medical advice.
- Discontinue use if irritation or allergic reaction occurs.
Missed Dose Advice
Not applicable as it is used for specific surgical procedures or hand hygiene protocols.
Driving Precautions
No known effects on ability to drive or operate machinery.
Lifestyle Advice
- Maintain good personal hygiene practices.
- Follow healthcare professional's instructions for wound care.
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