Medicine Information

Brodil-Levo

Name: Brodil-Levo
Brand: Brodil-Levo
Rating: 4.5 (117 reviews)

Inhaler50 mcgBronchodilatorATC: R03AC10

Generic Name

Levosalbutamol

Manufacturer

Aristopharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
brodil levo 50 mcg inhaler	৳ 250.00	N/A

Description

Overview of the medicine

Brodil-Levo 50 mcg Inhaler contains Levosalbutamol, a short-acting beta-agonist used to relieve bronchospasm in conditions like asthma and chronic obstructive pulmonary disease (COPD). It helps relax the muscles in the airways, making breathing easier.

Uses & Indications

Treatment or prevention of bronchospasm in adults, adolescents, and children 6 years of age and older with reversible obstructive airway disease.

Relief of symptoms associated with asthma and chronic obstructive pulmonary disease (COPD).

Dosage

Adults

The usual dosage for adults and adolescents 6 years of age and older is 1-2 puffs (50-100 mcg) every 4 to 6 hours as needed. Do not exceed 12 puffs in 24 hours.

Elderly

No specific dose adjustment is required, but caution should be exercised in elderly patients with co-morbidities, especially cardiovascular conditions.

Renal_impairment

No dose adjustment is typically required in patients with renal impairment, but clinical monitoring is advisable.

How to Take

For oral inhalation only. Shake the inhaler well before each use. Inhale slowly and deeply through the mouth while pressing down on the canister. Hold breath for as long as comfortable, then exhale slowly. Follow specific instructions provided with the device.

Mechanism of Action

Levosalbutamol is a selective beta-2 adrenergic receptor agonist. It stimulates beta-2 receptors in the bronchial smooth muscles, leading to relaxation of these muscles and subsequent bronchodilation. This action helps to open up the airways and improve airflow to the lungs.

Pharmacokinetics

Onset

Bronchodilation typically occurs within 5-10 minutes after inhalation.

Excretion

Excreted primarily in the urine, with a small amount excreted in feces.

Half life

The plasma elimination half-life is approximately 3.3-4 hours.

Absorption

Rapidly absorbed after oral inhalation, with systemic absorption occurring through the lungs and gastrointestinal tract.

Metabolism

Metabolized by sulfation in the liver to an inactive sulfate conjugate.

Side Effects

Contraindications

Hypersensitivity to levosalbutamol or any component of the inhaler.
Patients with severe milk protein allergy, as some formulations may contain lactose.

Drug Interactions

Diuretics

May potentiate the hypokalemic effect of beta-agonists. Monitor potassium levels.

Beta-blockers

May block the pulmonary effect of levosalbutamol and can produce severe bronchospasm in asthmatic patients. Concomitant use should generally be avoided.

MAOIs/Tricyclic Antidepressants

May potentiate the cardiovascular effects of levosalbutamol. Use with extreme caution.

Storage

Store below 30°C. Protect from direct sunlight, heat, and freezing. Keep out of reach of children. The canister is pressurized; do not puncture or incinerate.

Overdose

Symptoms of overdose include excessive beta-adrenergic stimulation (e.g., tachycardia, palpitations, tremor, nervousness), headache, and hypokalemia. Treatment is generally supportive and symptomatic. Consider cardioselective beta-blockers in severe cases, but with extreme caution due to potential for bronchospasm.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown if levosalbutamol is excreted in human milk; use with caution in nursing mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

100 metered doses per inhaler200 metered doses per inhaler

Shelf Life

Typically 2-3 years from the date of manufacture, specific expiry date mentioned on the packaging.

Availability

Available in pharmacies and hospitals nationwide

Approval Status

Generally approved by regulatory bodies (e.g., DGDA)

Patent Status

Patent expired for generic formulation

Clinical Trials

Levosalbutamol has undergone numerous clinical trials demonstrating its efficacy and safety in managing bronchospasm associated with asthma and COPD compared to racemic salbutamol and placebo.

Lab Monitoring

Monitor serum potassium levels, especially in patients receiving concomitant diuretics, corticosteroids, or xanthines, as beta-agonists can cause transient hypokalemia.

Doctor Notes

Educate patients on proper inhaler technique and the importance of using this as a rescue medication, not a maintenance therapy.
Caution patients against exceeding the prescribed dose due to potential cardiovascular adverse effects and paradoxical bronchospasm.
Assess for concomitant use of other bronchodilators or corticosteroids to ensure optimal asthma/COPD management.
Monitor patients with pre-existing cardiovascular conditions or hypokalemia risk factors closely.

Patient Guidelines

Follow your doctor's instructions regarding dose and frequency. Do not exceed the recommended dose.
Learn and practice proper inhaler technique to ensure the medicine reaches your lungs effectively.
If your symptoms worsen or the inhaler provides less relief than usual, seek medical attention immediately.
This inhaler is for quick relief of symptoms; it is not a substitute for long-term control medications.

Missed Dose Advice

If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Brodil-Levo 50 mcg Inhaler may cause side effects like tremor or dizziness in some individuals. If you experience these effects, avoid driving or operating machinery until you feel well.

Lifestyle Advice

Identify and avoid triggers that worsen your asthma or COPD symptoms (e.g., allergens, smoke, pollutants).
Maintain a healthy lifestyle, including regular exercise (as tolerated) and a balanced diet.
Quit smoking if you are a smoker, as it significantly worsens respiratory conditions.