Medicine Information

Lexotanil

Name: Lexotanil
Brand: Lexotanil
Rating: 4.5 (117 reviews)

Tablet3 mgAnxiolytics, BenzodiazepinesATC: N05BA08

Generic Name

Bromazepam

Manufacturer

Multiple manufacturers (e.g., Roche)

Country

Global (various countries)

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
bromazepam 3 mg tablet	৳ 4.50	৳ 45.00

Description

Overview of the medicine

Bromazepam is a benzodiazepine derivative with anxiolytic, sedative, hypnotic, anticonvulsant, and muscle relaxant properties. It is primarily used for the short-term treatment of severe anxiety or panic attacks.

Uses & Indications

Short-term symptomatic treatment of severe anxiety

Panic attacks

Mixed anxiety-depressive states where anxiety is prominent

Dosage

Adults

Initial 3-6 mg daily in divided doses, adjusted to 6-18 mg daily in divided doses; severe cases up to 30 mg daily.

Elderly

Initial dose 1.5-3 mg daily in divided doses; adjust carefully.

Renal_impairment

Dose reduction may be necessary; cautious titration.

How to Take

Oral administration with water, with or without food. Should be taken as prescribed by the doctor. Do not stop abruptly.

Mechanism of Action

Bromazepam acts by binding to specific benzodiazepine receptors on the GABA-A receptor complex in the central nervous system, enhancing the effects of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). This leads to increased chloride ion influx and hyperpolarization of the neuron, resulting in reduced neuronal excitability.

Pharmacokinetics

Onset

30-60 minutes

Excretion

Primarily excreted via the kidneys as metabolites, with a small amount unchanged.

Half life

10-20 hours (variable, may extend in elderly or liver impairment)

Absorption

Rapidly and extensively absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1-2 hours. Bioavailability is approximately 84%.

Metabolism

Extensively metabolized in the liver, primarily via cytochrome P450 enzymes (CYP3A4), forming active and inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to bromazepam or other benzodiazepines
Myasthenia gravis
Severe respiratory insufficiency
Severe hepatic insufficiency
Sleep apnea syndrome

Drug Interactions

Opioids

Increased risk of respiratory depression, sedation, and coma.

Antiepileptics

Enhanced sedative effects, altered seizure control.

Antifungals (e.g., ketoconazole)

May inhibit bromazepam metabolism, leading to increased plasma levels.

Alcohol and other CNS depressants

Enhanced sedative effects.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms include somnolence, confusion, lethargy, dysarthria, ataxia, hypotension, respiratory depression, and coma. Management involves supportive care and, in severe cases, flumazenil (a benzodiazepine antagonist) may be considered.

Pregnancy & Lactation

Category D in pregnancy (risk to fetus demonstrated). Not recommended during breastfeeding as it is excreted in breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets/blister30 tablets/box

Shelf Life

2-3 years from manufacturing date

Availability

Pharmacies, Hospitals

Approval Status

Approved by major regulatory bodies globally (e.g., FDA, EMA, DGDA)

Patent Status

Generic available; original patent expired

Clinical Trials

Numerous clinical trials have established the efficacy and safety of bromazepam in the short-term treatment of anxiety disorders, demonstrating its anxiolytic effects compared to placebo and other benzodiazepines.

Lab Monitoring

Liver function tests (especially in long-term use or hepatic impairment)

Doctor Notes

Emphasize short-term use only.
Educate patients on dependence and withdrawal.
Counsel on avoiding alcohol and interactions.
Gradual tapering is essential for discontinuation.

Patient Guidelines

Do not stop taking this medicine abruptly without consulting your doctor.
Avoid alcohol and other CNS depressants.
Be cautious when driving or operating machinery.
Report any unusual side effects to your doctor.

Missed Dose Advice

If a dose is missed, take it as soon as you remember, unless it is almost time for the next dose. Do not double the dose.

Driving Precautions

Bromazepam can cause drowsiness, dizziness, and impaired concentration. Do not drive or operate heavy machinery until you know how this medicine affects you.