Medicine Information

Bromofen

Name: Bromofen
Brand: Bromofen
Rating: 4.5 (117 reviews)

Eye Drop0.09%Ophthalmic NSAIDATC: S01BC11

Generic Name

Bromfenac Ophthalmic Solution

Manufacturer

Example Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
bromofen 009 eye drop	৳ 100.00	N/A

Description

Overview of the medicine

Bromofen 0.09% Eye Drop contains Bromfenac, a nonsteroidal anti-inflammatory drug (NSAID), used to treat inflammation and pain following cataract surgery.

Uses & Indications

Treatment of postoperative inflammation and pain in patients who have undergone cataract extraction.

Reduction of ocular swelling and discomfort after eye surgery.

Dosage

Adults

Instill one drop into the affected eye(s) twice daily, beginning 24 hours after surgery and continuing for 2 weeks.

Elderly

No dosage adjustment is necessary for elderly patients.

Renal_impairment

No dosage adjustment is necessary due to minimal systemic absorption.

How to Take

For ophthalmic use only. Tilt head back, pull down the lower eyelid to form a pouch, and instill one drop. Do not touch the dropper tip to any surface. Replace cap immediately after use.

Mechanism of Action

Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting prostaglandin synthesis, primarily by blocking the activity of cyclooxygenase (COX-1 and COX-2) enzymes. Prostaglandins are mediators of inflammation and pain in the eye.

Pharmacokinetics

Onset

Ocular anti-inflammatory effects typically begin within hours of initial application.

Excretion

Excretion of systemically absorbed bromfenac and its metabolites occurs primarily via urine.

Half life

Plasma half-life is approximately 1.5 hours, but ocular retention is longer, leading to sustained effects.

Absorption

Minimal systemic absorption after topical ocular administration. Peak ocular concentrations are achieved within 150-180 minutes.

Metabolism

Primarily metabolized by cytochrome P450 enzymes (mainly CYP2C9) to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to bromfenac or any components of the formulation.
History of aspirin-induced asthma, urticaria, or other allergic-type reactions to NSAIDs.

Drug Interactions

Topical Corticosteroids

May increase the potential for corneal healing problems, especially in compromised corneas. If co-administered, monitor carefully.

Storage

Store below 30°C in a dry place, away from direct sunlight. Do not freeze. Keep out of reach of children.

Overdose

Overdose is unlikely with topical ocular administration. If accidentally ingested, drink fluids to dilute. If eye irritation occurs, flush the eye with lukewarm water.

Pregnancy & Lactation

Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when administered to a nursing mother due to unknown systemic absorption.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

5 mL bottle

Shelf Life

2 years (unopened); 28 days after opening.

Availability

Pharmacies nationwide

Approval Status

Approved

Patent Status

Generic available

Clinical Trials

Clinical trials have demonstrated the efficacy and safety of bromfenac ophthalmic solution in reducing inflammation and pain following cataract surgery.

Lab Monitoring

No routine lab monitoring is required for ophthalmic bromfenac.

Doctor Notes

Advise patients on proper instillation technique to avoid contamination and maximize efficacy.
Monitor patients for signs of corneal compromise, especially with prolonged use or pre-existing conditions.

Patient Guidelines

Wash hands thoroughly before and after applying eye drops.
Remove contact lenses before application and wait at least 15 minutes before reinserting.
If using other ophthalmic medications, wait at least 5 minutes between applications.

Missed Dose Advice

If a dose is missed, apply it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.

Driving Precautions

May cause temporary blurred vision or discomfort immediately after instillation. Patients should be advised not to drive or operate machinery until vision clears.

Lifestyle Advice

Avoid rubbing your eyes after application.
Protect eyes from excessive light if photophobia occurs.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Bromfenac Eye Drop (Square Pharmaceuticals)Bromolac Eye Drop (Beximco Pharmaceuticals)

Global Brand Names

International brand names for this medicine

Incepta Pharmaceuticals Ltd.

Tablet500 mg

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