Medicine Information

Bronkolax

Name: Bronkolax
Brand: Bronkolax
Rating: 4.5 (117 reviews)

Syrup2 mg/5 mlBronchodilatorATC: R03AC02

Generic Name

Salbutamol

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
bronkolax 2 mg syrup	৳ 23.00	N/A

Description

Overview of the medicine

Bronkolax 2 mg syrup contains Salbutamol, a fast-acting bronchodilator used to relieve symptoms of asthma and chronic obstructive pulmonary disease (COPD).

Uses & Indications

Relief of bronchospasm in asthma and chronic obstructive pulmonary disease (COPD).

Prevention of exercise-induced bronchospasm.

Management of chronic asthma and reversible airway obstruction.

Dosage

Adults

Adults: 2 mg or 4 mg (5 ml or 10 ml) three or four times daily. A single dose of up to 20 ml (8 mg) may be given. Max 32 mg/day.

Elderly

Elderly: Initial dose 2 mg (5 ml) three or four times daily. Dosage may be increased to 4 mg (10 ml) three or four times daily if required.

Renal_impairment

No dosage adjustment typically required, but monitor response and consider reduced frequency if severe impairment.

How to Take

Take orally with or without food. Use a calibrated measuring spoon or cup provided with the syrup for accurate dosing. Shake the bottle well before each use.

Mechanism of Action

Salbutamol is a selective beta2-adrenergic agonist. It stimulates beta2-adrenergic receptors in the smooth muscle of the bronchi, leading to relaxation of bronchial smooth muscle and bronchodilation.

Pharmacokinetics

Onset

Bronchodilation typically occurs within 5-15 minutes after oral administration.

Excretion

Mainly excreted in urine within 72 hours as unchanged drug and its sulfate metabolite.

Half life

The plasma half-life of oral salbutamol is approximately 3.8 to 5 hours.

Absorption

Rapidly and well absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are reached within 2-3 hours.

Metabolism

Undergoes significant first-pass metabolism in the liver and gastrointestinal wall, primarily to an inactive sulfate conjugate.

Side Effects

Contraindications

Hypersensitivity to salbutamol or any component of the formulation.
Threatened abortion during the first or second trimester.
Use as a sole agent in patients with severe asthma or unstable asthma.

Drug Interactions

Digoxin

May decrease digoxin serum levels.

Diuretics (e.g., Furosemide)

May cause hypokalemia, increasing the risk of cardiac arrhythmias. Monitor potassium levels.

Beta-blockers (e.g., Propranolol)

May reduce the effect of salbutamol and cause severe bronchospasm. Concomitant use is generally contraindicated.

Monoamine Oxidase Inhibitors (MAOIs) / Tricyclic Antidepressants (TCAs)

Increased risk of cardiovascular side effects. Use with caution.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children. Do not freeze.

Overdose

Symptoms of overdose include tachycardia, tremors, palpitations, headache, hypokalemia, and hyperglycemia. Treatment is symptomatic and supportive, usually involving discontinuation of the drug and careful monitoring of vital signs and potassium levels.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Salbutamol is excreted in breast milk; use with caution in lactating mothers and weigh benefits against risks.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

50 ml syrup100 ml syrup

Shelf Life

Typically 24-36 months from the date of manufacture when stored under recommended conditions.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Salbutamol has been extensively studied and is a well-established treatment for asthma and COPD, with numerous clinical trials supporting its efficacy and safety profile. Ongoing research explores novel formulations and delivery methods.

Lab Monitoring

Monitor serum potassium levels, especially in patients receiving concomitant diuretics, corticosteroids, or xanthines, or in severe acute asthma.
Monitor blood glucose levels in diabetic patients.

Doctor Notes

Emphasize to patients the importance of not exceeding the prescribed dose to avoid adverse cardiovascular effects and hypokalemia.
Advise patients with frequent reliance on short-acting beta-agonists to consult for reassessment of their long-term asthma control therapy.
Caution against use in patients with pre-existing cardiac conditions without careful evaluation.

Patient Guidelines

Do not exceed the recommended dose as it may lead to adverse effects.
Always use the provided measuring device for accurate dosing.
If your symptoms worsen or do not improve, seek medical advice promptly.
Inform your doctor about all other medications you are taking.

Missed Dose Advice

If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Bronkolax syrup may cause tremor, dizziness, or nervousness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.

Lifestyle Advice

Avoid smoking to improve respiratory health and reduce asthma triggers.
Maintain a healthy weight and engage in regular physical activity as advised by your physician to improve overall lung function.