Medicine Information

Budesonide

Name: Budesonide
Brand: Budesonide
Rating: 4.5 (117 reviews)

Nasal Spray100 mcg per sprayCorticosteroidsATC: R01AD05

Generic Name

Budesonide 100 mcg Nasal Spray

Manufacturer

Various manufacturers globally (e.g., AstraZeneca as innovator)

Country

Global

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
budenide 100 mcg nasal spray	৳ 250.75	N/A

Description

Overview of the medicine

Budesonide nasal spray is a corticosteroid used to treat symptoms of allergic and non-allergic rhinitis, and to manage nasal polyps.

Uses & Indications

Treatment and prevention of symptoms associated with seasonal or perennial allergic rhinitis.

Treatment of non-allergic rhinitis (vasomotor rhinitis).

Management and prevention of recurrence of nasal polyps after polypectomy.

Dosage

Adults

Initial dose: 100 mcg (one spray) in each nostril once daily, or 50 mcg (one spray) in each nostril twice daily. Max 200 mcg/day per nostril. Maintenance dose should be the lowest effective dose.

Elderly

No specific dosage adjustment required, but caution is advised in elderly patients with comorbidities.

Renal_impairment

No dosage adjustment necessary.

How to Take

For intranasal use only. Shake the bottle gently before use. Clear nasal passages by blowing nose. Tilt head slightly forward, insert nozzle into nostril, and spray while sniffing gently. Repeat for the other nostril.

Mechanism of Action

Budesonide is a potent glucocorticoid with strong topical anti-inflammatory action. It reduces inflammation, swelling, and mucus production in the nasal passages by inhibiting the release of inflammatory mediators.

Pharmacokinetics

Onset

Clinical effects typically observed within hours, with full therapeutic benefit achieved within a few days to a week.

Excretion

Metabolites are primarily excreted via the urine and feces.

Half life

Approximately 2-3 hours for systemic budesonide.

Absorption

Low systemic bioavailability (approximately 6-20%) due to extensive first-pass metabolism in the liver.

Metabolism

Primarily metabolized in the liver by the cytochrome P450 3A4 (CYP3A4) isoenzyme.

Side Effects

Contraindications

Hypersensitivity to budesonide or any component of the formulation.
Untreated localized infection involving the nasal mucosa (e.g., herpes simplex).

Drug Interactions

Strong CYP3A4 inhibitors (e.g., Ketoconazole, Itraconazole, Ritonavir, Atazanavir)

May significantly increase systemic exposure to budesonide, potentially leading to Cushing's syndrome and adrenal suppression. Concurrent use should be avoided or dose adjusted.

Storage

Store upright at room temperature (15°C-30°C / 59°F-86°F). Do not freeze. Keep out of reach of children.

Overdose

Acute overdose with budesonide nasal spray is unlikely to produce serious systemic effects due to its low systemic bioavailability. Chronic excessive dosing may lead to signs and symptoms of hypercorticism.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Budesonide is excreted in human milk; caution should be exercised when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

120 metered sprays (10 mL bottle)60 metered sprays (5 mL bottle)

Shelf Life

Typically 2-3 years when unopened. Discard after the expiry date or a specified period after opening (e.g., 3 months).

Availability

Pharmacies, Hospitals

Approval Status

Approved by major regulatory bodies (e.g., FDA)

Patent Status

Generic available, original patent expired

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of budesonide nasal spray in treating allergic and non-allergic rhinitis and nasal polyps in adults and children.

Lab Monitoring

Routine lab monitoring is generally not required for nasal budesonide.
Monitor growth velocity in pediatric patients receiving long-term corticosteroid therapy.

Doctor Notes

Emphasize the importance of consistent daily use for optimal results, even during symptom-free periods.
Instruct patients on correct nasal spray technique to avoid nasal septal irritation and maximize drug delivery.
Advise patients to report any severe or persistent side effects, particularly nosebleeds or signs of infection.

Patient Guidelines

Use regularly as prescribed, even if symptoms improve.
Proper administration technique is crucial for effectiveness and to minimize side effects.
Avoid spraying directly onto the nasal septum.
Do not exceed the recommended dose.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose.