Medicine Information

Buticef

Name: Buticef
Brand: Buticef
Rating: 4.5 (117 reviews)

Oral Suspension90 mg/5 mlAntibioticsATC: J01DD08

Generic Name

Cefixime 90 mg Suspension

Manufacturer

Medicinova

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
buticef 90 mg suspension	৳ 480.00	N/A

Description

Overview of the medicine

Buticef 90 mg Suspension contains Cefixime, which is a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections in children.

Uses & Indications

Otitis Media (middle ear infection)

Pharyngitis and Tonsillitis (sore throat and tonsil infection)

Bronchitis (inflammation of the bronchial tubes)

Urinary Tract Infections (UTIs)

Gonorrhea (uncomplicated)

Dosage

Elderly

No specific dose adjustment is required for elderly patients unless they have severe renal impairment.

Children

For children aged 6 months to 12 years: 8 mg/kg/day administered as a single dose or in two divided doses. Duration of treatment usually 5-10 days, depending on the infection. Maximum daily dose should not exceed 400 mg.

Renal_impairment

Dosage adjustment is recommended for patients with creatinine clearance less than 60 mL/min. For moderate impairment (20-49 mL/min), the dose should be reduced by 25%. For severe impairment (< 20 mL/min), the dose should be reduced by 50%.

How to Take

Buticef 90 mg Suspension should be taken orally, with or without food. Shake the bottle well before each use to ensure uniform dosage. Use the provided measuring cup or syringe for accurate dosing.

Mechanism of Action

Cefixime exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) which leads to inhibition of the transpeptidation step of peptidoglycan synthesis, thereby disrupting cell wall formation and causing bacterial cell lysis.

Pharmacokinetics

Onset

Peak plasma concentrations are achieved 2-6 hours after administration.

Excretion

Approximately 50% is excreted unchanged in the urine over 24 hours, and some is excreted via biliary/fecal route.

Half life

Plasma half-life averages 3-4 hours.

Absorption

Approximately 40-50% orally absorbed, independent of food.

Metabolism

Not extensively metabolized in the liver; primarily excreted unchanged.

Side Effects

Contraindications

Hypersensitivity to Cefixime or any other cephalosporin antibiotics.
History of anaphylactic reactions to penicillin or other beta-lactam antibiotics.

Drug Interactions

Warfarin

May increase prothrombin time and INR, leading to increased bleeding risk. Close monitoring of coagulation parameters is advised.

Carbamazepine

Concomitant use may increase carbamazepine plasma levels. Monitor carbamazepine levels.

Oral Contraceptives

May reduce the efficacy of oral contraceptives. Advise patients to use an additional non-hormonal birth control method.

Aminoglycosides / Loop Diuretics

May increase the risk of nephrotoxicity.

Storage

Store the dry powder below 30°C in a dry place, away from direct sunlight and moisture. Keep the reconstituted suspension refrigerated (2-8°C) and discard any unused portion after 14 days.

Overdose

In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be supportive and symptomatic.

Pregnancy & Lactation

Pregnancy Category B. Animal reproduction studies have shown no evidence of harm to the fetus. However, use in pregnancy should be only if clearly needed. Cefixime is excreted in human milk in small amounts; use with caution during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 ml suspension50 ml suspension100 ml suspension

Shelf Life

24 months for unreconstituted powder. Reconstituted suspension is stable for 7 days at room temperature (25°C) or 14 days under refrigeration (2-8°C).

Availability

Pharmacies, Hospitals

Approval Status

Approved by major regulatory bodies

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in treating various bacterial infections in pediatric and adult populations. Studies have supported its use for respiratory tract infections, UTIs, and otitis media.

Lab Monitoring

Complete blood count (CBC) for prolonged therapy
Renal function tests (blood urea nitrogen, creatinine) in patients with pre-existing renal impairment or during long-term therapy
Liver function tests (LFTs) if abnormalities are suspected or during prolonged therapy.

Doctor Notes

Educate parents/caregivers on the importance of completing the full antibiotic course, even if symptoms improve, to prevent resistance.
Advise on proper reconstitution (if applicable) and accurate measurement of doses using the provided device.
Monitor for signs of allergic reactions, including rash, itching, or swelling, and instruct to seek immediate medical attention if these occur.
Counsel on potential gastrointestinal side effects and advise hydration.

Patient Guidelines

Take the full course of medicine as prescribed, even if symptoms improve, to prevent recurrence and antibiotic resistance.
Shake the suspension well before each use.
Use the provided measuring device to ensure accurate dosing.
Do not store any leftover medicine for future infections.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Buticef 90 mg Suspension usually does not affect the ability to drive or operate machinery. However, if side effects like dizziness occur, avoid such activities.