Medicine Information

Candirox

Name: Candirox
Brand: Candirox
Rating: 4.5 (117 reviews)

Nail Lacquer8% w/wTopical AntifungalATC: D01AE14

Generic Name

Ciclopirox 8% w/w Nail Lacquer

Manufacturer

Apotex Inc.

Country

Canada

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
candirox 8 w nail lacquer	৳ 160.00	N/A

Description

Overview of the medicine

Candirox 8% w/w Nail Lacquer contains Ciclopirox, an antifungal agent used for the treatment of fungal infections of the nails (onychomycosis), especially those caused by dermatophytes, yeasts, and molds.

Uses & Indications

Onychomycosis (fungal infection of the nails) caused by dermatophytes, yeasts, and molds

Treatment of mild to moderate onychomycosis without lunula involvement.

Dosage

Adults

Apply to the affected nails once daily for up to 48 weeks. Treatment duration depends on the severity of the infection and the rate of nail growth.

Elderly

No specific dosage adjustment required.

Renal_impairment

No specific dosage adjustment required for topical use, as systemic absorption is minimal.

How to Take

Apply a thin layer of the lacquer over the entire surface of the affected nail and the surrounding skin once daily, preferably at bedtime. Once a week, remove the old lacquer with an alcohol swab before new application. If a coat is missed, apply it as soon as remembered.

Mechanism of Action

Ciclopirox inhibits the growth of fungal cells by chelating polyvalent cations (e.g., Fe3+, Al3+) resulting in the inhibition of metal-dependent enzymes, which are critical for fungal cell metabolism and integrity. It also disrupts fungal cell membrane function.

Pharmacokinetics

Onset

Clinical improvement usually observed after 3-6 months; complete clearance may take up to 9-12 months.

Excretion

Excreted via kidneys, primarily as glucuronides.

Half life

Not well-characterized for topical nail application, but systemic half-life is approximately 1.7 hours.

Absorption

Minimal systemic absorption after topical application to nails. Less than 5% of the dose is absorbed systemically.

Metabolism

Minimal metabolism at the application site. Absorbed Ciclopirox is primarily metabolized by glucuronidation.

Side Effects

Contraindications

Hypersensitivity to Ciclopirox or any components of the formulation
Children under 12 years of age (safety and efficacy not established)

Drug Interactions

N/A

Minimal systemic absorption, so significant drug interactions are unlikely with topical application.

Storage

Store below 25°C. Protect from light and moisture. Keep tightly closed. Keep away from heat and open flame.

Overdose

Topical overdose is unlikely to cause systemic toxicity due to minimal absorption. In case of accidental ingestion, seek medical advice.

Pregnancy & Lactation

Use with caution during pregnancy and lactation only if the potential benefit justifies the potential risk to the fetus/infant. Consult a doctor before use.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

3 ml bottle6 ml bottle

Shelf Life

24 months

Availability

Pharmacies

Approval Status

Approved by regulatory authorities

Patent Status

Patent expired

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of Ciclopirox nail lacquer for onychomycosis.

Lab Monitoring

No specific lab monitoring is required for topical Ciclopirox nail lacquer.

Doctor Notes

Emphasize patient compliance for the full duration of treatment (up to 48 weeks).
Advise patients on proper nail hygiene and removal of non-viable nail material.
Consider combination therapy for severe cases or those with matrix involvement.

Patient Guidelines

Use only as directed by your doctor.
Apply to the affected nails and surrounding skin only.
Avoid contact with eyes and mucous membranes.
Do not use nail polish or other cosmetic nail products on treated nails.
File down loose nail material weekly as instructed by your doctor.
Treatment duration can be lengthy, continue as prescribed.

Missed Dose Advice

If a dose is missed, apply it as soon as remembered. Do not apply a double dose to make up for a missed dose.

Driving Precautions

Candirox 8% w/w Nail Lacquer has no known effect on the ability to drive or operate machinery.

Lifestyle Advice

Keep nails trimmed and clean.
Wear breathable footwear and change socks daily.
Avoid walking barefoot in public damp areas (e.g., swimming pools, locker rooms).