Medicine Information

Cefaz

Name: Cefaz
Brand: Cefaz
Rating: 4.5 (117 reviews)

Powder for injection2 gmAnti-bacterial (1st generation Cephalosporins)ATC: J01DB01

Generic Name

Cefazolin

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
cefaz 2 gm injection	৳ 300.00	N/A

Description

Overview of the medicine

Cefaz 2 gm Injection contains Cefazolin, a first-generation cephalosporin antibiotic used to treat a variety of bacterial infections and for surgical prophylaxis. It is administered intravenously or intramuscularly.

Uses & Indications

Treatment of respiratory tract infections

Urinary tract infections

Skin and soft tissue infections

Bone and joint infections

Surgical prophylaxis

Dosage

Adults

Typical adult dose for moderate to severe infections is 500 mg to 1 gm every 6 to 8 hours. For surgical prophylaxis, 1 gm IV/IM 30-60 minutes prior to surgery, then 500 mg to 1 gm every 6-8 hours for 24 hours.

Elderly

Dose adjustment may be necessary in elderly patients with impaired renal function.

Renal_impairment

Dosage must be adjusted based on creatinine clearance.

How to Take

For IV administration, reconstitute with sterile water for injection and administer slowly over 3-5 minutes or infuse over 30-60 minutes. For IM administration, reconstitute with sterile water or lidocaine and inject deep into a large muscle mass.

Mechanism of Action

Cefazolin is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death.

Pharmacokinetics

Onset

Rapid, typically within minutes of IV administration.

Excretion

Primarily via renal excretion (glomerular filtration and tubular secretion).

Half life

Approximately 1.8 hours.

Absorption

Rapidly and completely absorbed after intramuscular (IM) administration; high bioavailability.

Metabolism

Minimally metabolized; primarily excreted unchanged.

Side Effects

Contraindications

Hypersensitivity to cefazolin or any other cephalosporin antibiotics
History of severe hypersensitivity reaction to penicillin (due to potential cross-reactivity)

Drug Interactions

Probenecid

Increases and prolongs cefazolin plasma levels by decreasing renal tubular secretion.

Anticoagulants (e.g., Warfarin)

May enhance anticoagulant effect; monitor INR.

Nephrotoxic drugs (e.g., Aminoglycosides, Furosemide)

Increased risk of nephrotoxicity.

Storage

Store powder for injection at controlled room temperature (20-25°C) away from moisture and light. Reconstituted solutions should be stored as per specific instructions, usually refrigerated.

Overdose

Symptoms of overdose may include seizures, neurological toxicity. Management involves supportive care and hemodialysis if severe renal impairment exists.

Pregnancy & Lactation

Pregnancy Category B. Cefazolin crosses the placenta. Use in pregnancy only if clearly needed. Excreted in breast milk in low concentrations; caution advised during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 vial (2 gm)

Shelf Life

Typically 2-3 years for unopened vials when stored as recommended. Reconstituted solutions have a shorter shelf life (e.g., 24 hours at room temperature, 10 days refrigerated).

Availability

Hospitals, Clinics, Retail Pharmacies

Approval Status

Approved by major regulatory bodies (e.g., FDA, DGDA)

Patent Status

Off-patent (generic available)

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established cefazolin's efficacy and safety for indicated bacterial infections and surgical prophylaxis since its introduction.

Lab Monitoring

Renal function tests (e.g., creatinine, BUN) during prolonged therapy or in patients with renal impairment
Complete blood count (CBC) during prolonged therapy
Liver function tests (LFTs) if abnormalities are suspected

Doctor Notes

Careful history taking regarding penicillin allergy is crucial due to potential cross-reactivity.
Monitor renal function in patients receiving high doses or with pre-existing renal impairment.
Administer slowly to avoid vein irritation with IV administration.

Patient Guidelines

Report any signs of allergic reaction immediately.
Complete the full course of treatment even if symptoms improve.
Inform your doctor about all other medications you are taking.
Report any persistent diarrhea or severe stomach cramps.

Missed Dose Advice

If a dose is missed, administer it as soon as possible. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.

Driving Precautions

Cefazolin is generally not expected to impair the ability to drive or operate machinery. However, if side effects like dizziness occur, advise caution.