Medicine Information

Clindax

Name: Clindax
Brand: Clindax
Rating: 4.5 (117 reviews)

Injection300 mg/2 mlAntibacterial (Lincosamide)ATC: J01FF01

Generic Name

Clindamycin

Manufacturer

Ziska Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
clindax 300 mg injection	৳ 40.15	N/A

Description

Overview of the medicine

Clindax 300 mg Injection contains Clindamycin, a lincosamide antibiotic used to treat various serious bacterial infections. It works by stopping the growth of bacteria.

Uses & Indications

Serious infections caused by susceptible anaerobic bacteria

Streptococcal and staphylococcal infections (e.g., skin and soft tissue infections)

Intra-abdominal infections

Pelvic inflammatory disease (in combination with other antibiotics)

Lower respiratory tract infections (e.g., pneumonia, empyema)

Bone and joint infections (e.g., osteomyelitis)

Dosage

Adults

300-600 mg every 6-8 hours, administered intramuscularly (IM) or intravenously (IV). For severe infections, doses up to 2.7 g/day (in 2-4 equally divided doses) may be given. IV infusion should be administered slowly over 10-60 minutes.

Elderly

Similar to adult dosage; monitor for any age-related decrease in organ function.

Renal_impairment

No dose adjustment is generally required for mild to moderate renal impairment. For severe impairment, dose adjustment may not be necessary if given every 8 hours, but monitoring is advised.

How to Take

Clindax Injection can be administered either intramuscularly (IM) or by intravenous (IV) infusion. For IV use, the solution must be diluted before infusion and administered over at least 10-60 minutes; do not administer as a bolus injection. IM injections should be given deep into a large muscle.

Mechanism of Action

Clindamycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing peptide chain elongation.

Pharmacokinetics

Onset

Rapidly achieved peak plasma concentrations after IM injection (within 3 hours); immediate with IV infusion.

Excretion

Approximately 10-20% excreted in urine, and a larger portion (about 30-40%) excreted in feces via bile. The remainder is excreted as inactive metabolites.

Half life

Approximately 2-3 hours in adults with normal renal and hepatic function.

Absorption

Rapid and complete absorption after intramuscular (IM) administration. Intravenous (IV) administration provides immediate systemic availability.

Metabolism

Extensively metabolized in the liver to active (e.g., N-demethyl clindamycin) and inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to clindamycin or lincomycin
History of antibiotic-associated colitis

Drug Interactions

Erythromycin

Due to antagonistic effects, clindamycin and erythromycin should not be administered concurrently.

Opioid analgesics

May increase the risk of respiratory depression when co-administered.

Neuromuscular blocking agents

Clindamycin has neuromuscular blocking properties and may enhance the action of other neuromuscular blocking agents, leading to increased muscle weakness.

Storage

Store below 30°C. Do not freeze. Protect from light. Keep out of reach of children.

Overdose

In case of overdose, symptomatic and supportive treatment is recommended. Hemodialysis and peritoneal dialysis are not effective in removing clindamycin from the blood.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. It should be used during pregnancy only if clearly needed. Clindamycin is excreted in human milk; caution is advised when administered to a nursing mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

Single 2 ml vialBox of 5 x 2 ml vials

Shelf Life

Typically 2-3 years from the date of manufacture, specific details on packaging.

Availability

Hospitals, pharmacies

Approval Status

Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Clindamycin has been extensively studied in numerous clinical trials demonstrating its efficacy in treating a wide range of bacterial infections. Ongoing research may explore new indications or formulations.

Lab Monitoring

Liver and kidney function tests (for prolonged therapy)
Complete Blood Count (CBC)

Doctor Notes

Emphasize the importance of completing the full course of treatment.
Educate patients on the risk of *C. difficile*-associated diarrhea and advise them to seek medical attention for severe, persistent diarrhea.
Consider alternative agents or dose adjustment in patients with significant hepatic impairment, though clindamycin is not primarily renally eliminated.

Patient Guidelines

Complete the full course of treatment as prescribed by your doctor, even if symptoms improve.
Report any severe or persistent diarrhea to your doctor immediately.
Inform your doctor about any known allergies or medical conditions before starting treatment.

Missed Dose Advice

If a dose of Clindax Injection is missed, administer it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Clindamycin is generally not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.