Deslor
Generic Name
deslor-25-mg-syrup
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| deslor 25 mg syrup | ৳ 30.09 | N/A |
Description
Overview of the medicine
Desloratadine is a non-sedating antihistamine that provides relief from allergy symptoms such as sneezing, runny nose, itching, and hives. It is effective in treating allergic rhinitis and chronic idiopathic urticaria.
Uses & Indications
Dosage
Adults
5 mg (10 ml of 2.5 mg/5 ml syrup) orally once daily.
Elderly
No specific dose adjustment required; usual adult dose of 5 mg once daily.
Renal_impairment
For severe renal impairment (creatinine clearance <30 mL/min), administer 5 mg every other day. Consult physician for dosage adjustment.
How to Take
Administer orally, with or without food. Use the provided measuring device to ensure accurate dosing, especially for children.
Mechanism of Action
Desloratadine is a potent, selective, peripheral H1-receptor antagonist. It prevents histamine from binding to H1 receptors, thereby reducing the allergic response. It also has anti-inflammatory properties.
Pharmacokinetics
Onset
Within 30 minutes to 1 hour.
Excretion
Primarily excreted in urine (40%) and feces (40%) as metabolites.
Half life
Approximately 27 hours.
Absorption
Rapidly absorbed after oral administration, reaching peak plasma concentrations in approximately 3 hours.
Metabolism
Extensively metabolized to 3-hydroxydesloratadine, an active metabolite, primarily by CYP2C8, CYP2D6, and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- Patients with severe liver impairment without medical consultation.
Drug Interactions
Cimetidine
Increased plasma concentration of desloratadine.
Fluoxetine
Increased plasma concentration of desloratadine.
Azithromycin
Increased plasma concentration of desloratadine.
Erythromycin
Increased plasma concentration of desloratadine.
Ketoconazole
Increased plasma concentration of desloratadine.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, and headache. In case of overdose, initiate symptomatic and supportive treatment. Desloratadine is not eliminated by hemodialysis.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted into breast milk; caution should be exercised when administered to a nursing mother. Consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture, specific to manufacturer.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
Clinical Trials
Desloratadine has undergone extensive clinical trials demonstrating its efficacy and safety in various allergic conditions across different age groups, including pediatric populations.
Lab Monitoring
- No routine laboratory monitoring is typically required.
Doctor Notes
- Emphasize the importance of accurate dosing for pediatric patients using the provided measuring device.
- Advise patients to report any unusual or severe side effects immediately.
Patient Guidelines
- Do not exceed the recommended dose.
- For children, use the provided measuring spoon or cup for accurate dosing.
- Inform your doctor or pharmacist about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Although desloratadine is generally non-sedating, some individuals may experience drowsiness. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Avoid alcohol consumption, as it may enhance CNS depressant effects.
- Stay hydrated.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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