Medicine Information

dompa-s

Name: dompa-s
Brand: dompa-s
Rating: 4.5 (117 reviews)

Suspension5 mg/5 mLAntiemetic, ProkineticATC: A03FA03

Generic Name

Domperidone

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
dompa s 5 mg suspension	৳ 28.00	N/A

Description

Overview of the medicine

Domperidone is a dopamine antagonist used to treat nausea, vomiting, and gastrointestinal motility disorders. It works by blocking dopamine receptors in the central nervous system and the gut.

Uses & Indications

Nausea and vomiting of various etiologies (e.g., post-chemotherapy, post-radiation, drug-induced)

Non-ulcer dyspepsia

Gastroparesis (diabetic, post-surgical)

Gastro-oesophageal reflux disease (GERD) as an adjunct to other treatments

Dosage

Adults

10-20 mg (2-4 teaspoons of 5 mg/5 mL suspension) three to four times daily, 15-30 minutes before meals and at bedtime. Maximum daily dose: 80 mg.

Elderly

Start with a lower dose (e.g., 10 mg three times daily) and monitor for adverse effects.

Renal_impairment

In severe renal impairment (creatinine clearance < 30 mL/min), frequency of dosing should be reduced to once or twice daily, depending on severity.

How to Take

Take orally, preferably 15-30 minutes before meals. Shake the suspension well before use.

Mechanism of Action

Domperidone blocks dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) located outside the blood-brain barrier and in the gastrointestinal tract. This action leads to increased gastric emptying and intestinal peristalsis, and an antiemetic effect.

Pharmacokinetics

Onset

30-60 minutes (oral)

Excretion

Approximately 66% excreted in feces and 33% in urine over several days, mainly as metabolites.

Half life

7-9 hours in healthy subjects, may be prolonged in severe renal impairment.

Absorption

Rapidly absorbed after oral administration, but undergoes extensive first-pass metabolism, resulting in low absolute bioavailability (approximately 15%). Food can delay absorption.

Metabolism

Extensively metabolized in the liver by hydroxylation and N-dealkylation, primarily via CYP3A4.

Side Effects

Contraindications

Known hypersensitivity to domperidone or any component of the formulation
Prolactin-secreting pituitary tumor (prolactinoma)
Moderate to severe hepatic impairment
Conditions where stimulation of gastric motility is dangerous (e.g., gastrointestinal hemorrhage, mechanical obstruction, perforation)
Patients with known prolonged QT intervals, significant electrolyte disturbances (hypokalemia, hypomagnesemia), or pre-existing cardiac disease (e.g., congestive heart failure)
Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, clarithromycin)

Drug Interactions

Dopamine agonists (e.g., bromocriptine, cabergoline)

Domperidone may antagonize their effects.

Antacids and antisecretory agents (e.g., proton pump inhibitors)

May reduce the oral bioavailability of domperidone if taken concomitantly. Should be taken before domperidone.

Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, clarithromycin)

Increased plasma concentrations of domperidone, leading to a higher risk of QT prolongation and cardiac arrhythmias. Concomitant use is contraindicated.

QT-prolonging drugs (e.g., antiarrhythmics, antipsychotics, antidepressants)

Increased risk of QT prolongation and ventricular arrhythmias. Concomitant use should be avoided or used with extreme caution.

Storage

Store below 30°C in a dry place, protected from light and moisture. Do not freeze. Keep out of reach of children.

Overdose

Symptoms of overdose may include somnolence, disorientation, and extrapyramidal reactions, particularly in children. Treatment is symptomatic and supportive; gastric lavage may be performed, and activated charcoal may be given. Anticholinergic, anti-parkinsonian drugs may be useful for extrapyramidal reactions.

Pregnancy & Lactation

Pregnancy Category C. Studies in animals have shown reproductive toxicity. Not recommended during pregnancy unless the potential benefits outweigh the potential risks. Domperidone is excreted in breast milk in small amounts; use with caution in nursing mothers, especially in infants with cardiac risk factors.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

60 mL bottle100 mL bottle

Shelf Life

Typically 24 to 36 months from the date of manufacture when stored correctly.

Availability

Pharmacies, Hospitals

Approval Status

Approved (General)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have established domperidone's efficacy in treating functional dyspepsia, gastroparesis, and drug-induced nausea and vomiting. Ongoing research focuses on its safety profile, particularly cardiac risks, and optimal dosing strategies.

Lab Monitoring

ECG monitoring (especially in patients with cardiac risk factors or on higher doses)
Electrolyte levels (potassium, magnesium) if there's a risk of imbalance

Doctor Notes

Emphasize the importance of not exceeding the recommended dose due to cardiac risks.
Carefully assess patients for pre-existing cardiac conditions, electrolyte imbalances, and concomitant use of QT-prolonging drugs or strong CYP3A4 inhibitors.
Consider alternative treatments for long-term use, especially in high-risk patients.
Monitor for signs of hyperprolactinemia with chronic use.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Do not exceed the recommended dose to avoid potential cardiac risks.
Report any symptoms like palpitations, dizziness, or fainting to your doctor immediately.
Take before meals for best results.

Missed Dose Advice

If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Domperidone may cause dizziness or somnolence. Patients should be advised to exercise caution when driving or operating machinery until they know how the medicine affects them.

Lifestyle Advice

Avoid alcohol, as it may exacerbate gastrointestinal symptoms.
Maintain a healthy diet and lifestyle to support digestive health.
Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements.