Medicine Information

Elygyl

Name: Elygyl
Brand: Elygyl
Rating: 4.5 (117 reviews)

Suspension200 mg per 5 mlAnti-amoebic, Anti-protozoal, Anti-bacterialATC: P01AB01

Generic Name

elygyl-200-mg-suspension

Manufacturer

Popular Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
elygyl 200 mg suspension	৳ 22.00	N/A

Description

Overview of the medicine

Elygyl 200 mg Suspension contains Metronidazole, an antimicrobial medication used to treat various infections caused by anaerobic bacteria and certain parasites. It is effective against infections of the gastrointestinal tract, skin, joints, and respiratory system. The suspension form is suitable for pediatric patients or those who have difficulty swallowing tablets.

Uses & Indications

Amoebiasis (intestinal and hepatic)

Giardiasis

Trichomoniasis

Anaerobic bacterial infections (e.g., intra-abdominal, skin and soft tissue, gynecological, bone and joint)

Pseudomembranous colitis (C. difficile-associated diarrhea)

H. pylori eradication (as part of multi-drug regimen)

Dosage

Adults

Varies greatly by indication. E.g., Amoebiasis: 500-750 mg orally 3 times daily for 5-10 days. Anaerobic infections: 500 mg orally 3 times daily for 7-10 days.

Elderly

Dosage adjustment may be required in elderly patients with hepatic impairment. Otherwise, generally same as adults.

Renal_impairment

No dosage adjustment typically needed for renal impairment, but caution in severe cases due to metabolite accumulation.

How to Take

Take orally, preferably with or after food to minimize gastrointestinal upset. Shake the suspension well before use.

Mechanism of Action

Metronidazole enters microbial cells, where its nitro group is reduced by electron transport proteins. This reduction forms highly reactive nitro-radical anions that disrupt DNA synthesis and cause DNA damage, leading to microbial cell death. It is bactericidal against anaerobic bacteria and parasiticidal against protozoa.

Pharmacokinetics

Onset

Varies by infection, typically within hours to days.

Excretion

Mainly renal (60-80% as metabolites and unchanged drug); some fecal excretion.

Half life

Approximately 8 hours (range 6-12 hours).

Absorption

Well absorbed orally, bioavailability approximately 80%. Peak plasma concentrations within 1-2 hours.

Metabolism

Primarily hepatic by oxidation and glucuronidation. Major metabolite is 2-hydroxymethylmetronidazole, which also has some antibacterial activity.

Side Effects

Contraindications

Hypersensitivity to metronidazole or other nitroimidazole derivatives.
First trimester of pregnancy (relative contraindication, use with caution).

Drug Interactions

Alcohol

Disulfiram-like reaction (nausea, vomiting, flushing, tachycardia). AVOID alcohol during treatment and for at least 3 days after.

Lithium

Increases plasma lithium levels, leading to toxicity.

Warfarin

Enhances anticoagulant effect, increasing bleeding risk.

Disulfiram

Psychotic reactions.

Phenytoin, Phenobarbital

Decreases metronidazole levels.

Storage

Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.

Overdose

Symptoms include nausea, vomiting, ataxia, seizures, peripheral neuropathy. Management is supportive and symptomatic; no specific antidote.

Pregnancy & Lactation

Pregnancy Category B (US FDA). Generally considered safe in the second and third trimesters, but caution in the first trimester. Excreted into breast milk; advise to pump and discard milk for 12-24 hours after a single dose or consider an alternative.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

60 ml suspension100 ml suspension

Shelf Life

24-36 months (unopened), typically 14 days after opening.

Availability

Pharmacies, Hospitals

Approval Status

Approved by most regulatory bodies

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Metronidazole has been extensively studied since its introduction in the 1960s. Numerous clinical trials have established its efficacy and safety for various bacterial and parasitic infections.

Lab Monitoring

Liver function tests (LFTs) if prolonged treatment or hepatic impairment.
Complete blood count (CBC) if prolonged use.

Doctor Notes

Counsel patients on the importance of avoiding alcohol.
Monitor for neurological adverse effects, especially with long-term therapy.
Consider alternative treatment for pregnant women in the first trimester if possible.

Patient Guidelines

Complete the full course of treatment, even if symptoms improve, to prevent resistance and relapse.
Avoid alcohol during and for at least 3 days after treatment.
Report any severe side effects or allergic reactions to your doctor.

Missed Dose Advice

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.

Driving Precautions

May cause dizziness or drowsiness; caution when driving or operating machinery.

Lifestyle Advice

Maintain good hygiene to prevent reinfection, especially for parasitic infections.
Follow a balanced diet.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Metril (Square Pharmaceuticals Ltd.)Amotril (Beximco Pharmaceuticals Ltd.)Amodis (ACI Limited)

Global Brand Names

International brand names for this medicine

Square Pharmaceuticals Ltd.

Tablet500 mg

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