Eporise

Clinical Trials

Epoetin alfa has undergone numerous clinical trials demonstrating its efficacy and safety in various anemia indications. Ongoing research explores new applications and improved formulations.

Lab Monitoring

• Hemoglobin and hematocrit levels (regularly)
• Serum ferritin, transferrin saturation (TSAT)
• Blood pressure
• Renal function

Doctor Notes

• Closely monitor hemoglobin levels to avoid exceeding target ranges (10-11 g/dL for CKD). High hemoglobin levels are associated with increased cardiovascular risk.
• Assess iron status (ferritin, TSAT) before and during treatment; iron supplementation is often required for optimal response.
• Educate patients on potential adverse effects, especially symptoms of thrombosis (e.g., pain/swelling in leg, sudden chest pain) or uncontrolled hypertension (e.g., severe headache, blurred vision).
• Adjust dose incrementally, do not increase dose more frequently than once every 4 weeks.

Patient Guidelines

• Follow dosage instructions precisely as prescribed by your doctor.
• Do not shake the vial or pre-filled syringe.
• Report any unusual symptoms immediately, especially severe headache, vision changes, or signs of blood clots.
• Keep regular appointments for blood tests and blood pressure checks.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Driving Precautions

Epoetin alfa is not known to affect the ability to drive or operate machinery. However, if side effects like seizures, severe headache, or vision disturbances occur, avoid such activities.

Lifestyle Advice

• Maintain a healthy and balanced diet, rich in iron.
• Manage underlying conditions like hypertension with diet and medication.
• Avoid smoking and excessive alcohol consumption.