Medicine Information

Esoclip

Name: Esoclip
Brand: Esoclip
Rating: 4.5 (117 reviews)

Capsule20 mgProton Pump Inhibitor (PPI)ATC: A02BC05

Generic Name

Esomeprazole

Manufacturer

Incepta Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
esoclip 20 mg capsule	৳ 6.00	৳ 60.00

Description

Overview of the medicine

Esomeprazole is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach. It is used to treat acid-related conditions like gastroesophageal reflux disease (GERD), peptic ulcers, and to prevent NSAID-induced ulcers.

Uses & Indications

Gastroesophageal Reflux Disease (GERD)

Erosive Esophagitis

Healing of NSAID-associated gastric ulcers

H. pylori eradication (in combination with antibiotics)

Zollinger-Ellison Syndrome

Dosage

Adults

GERD/Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks. NSAID-ulcers: 20 mg once daily for 4-8 weeks. H. pylori eradication: 20 mg twice daily for 7-14 days (with antibiotics). Zollinger-Ellison: Initial 40 mg twice daily, adjusted as needed.

Elderly

No dose adjustment generally required. Use with caution in severe hepatic impairment.

Renal_impairment

No dose adjustment required.

How to Take

Take capsule whole, at least one hour before a meal. Do not chew or crush the capsule. For patients with swallowing difficulties, the capsule can be opened, and the pellets mixed with a small amount of water or fruit juice (do not crush pellets), and drunk immediately.

Mechanism of Action

Esomeprazole is an S-isomer of omeprazole. It selectively inhibits the H+/K+-ATPase enzyme system (the proton pump) at the secretory surface of the gastric parietal cells, thereby blocking the final step of acid secretion.

Pharmacokinetics

Onset

Within 1 hour

Excretion

Primarily renal (80%) as metabolites, rest in feces.

Half life

Approximately 1-1.5 hours

Absorption

Rapidly absorbed after oral administration. Bioavailability increases with repeated doses. Food delays and decreases absorption.

Metabolism

Extensively hepatic metabolism by CYP2C19 and CYP3A4.

Side Effects

Contraindications

Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
Concomitant use with nelfinavir.

Drug Interactions

Diazepam

May decrease clearance of diazepam (CYP2C19 substrate).

Warfarin

Increased INR/prothrombin time; monitor closely.

Tacrolimus

Increased tacrolimus serum concentrations.

Clopidogrel

May reduce antiplatelet effect of clopidogrel (avoid concomitant use if possible).

Methotrexate

Increased plasma levels of methotrexate (monitor for toxicity).

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Limited experience with overdose. Symptoms may include drowsiness, tachycardia, nausea, diarrhea, abdominal pain, and headache. Treatment is symptomatic and supportive.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have shown no risk, but human studies are lacking. Use only if clearly needed. Excreted in breast milk, so caution is advised; weigh benefits vs. risks.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules14 capsules30 capsules

Shelf Life

24-36 months (check specific packaging)

Availability

Pharmacies, hospitals

Approval Status

Approved by regulatory authorities (e.g., DGDA)

Patent Status

Generics available, patent expired

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials support its efficacy and safety for approved indications. Ongoing post-marketing surveillance.

Lab Monitoring

Electrolytes (e.g., magnesium, potassium, calcium) for long-term use.
INR/Prothrombin time if on warfarin.
Chromogranin A (CgA) levels for neuroendocrine tumors (PPIs can elevate CgA).

Doctor Notes

Advise patients on lifestyle modifications.
Consider lowest effective dose for shortest duration.
Monitor for long-term adverse effects like hypomagnesemia and bone density changes.
Rule out malignancy before initiating therapy for dyspepsia.

Patient Guidelines

Take exactly as prescribed.
Do not crush or chew the capsule.
Take before a meal, preferably in the morning.
Inform your doctor about all other medications you are taking.
Long-term use may require bone density and magnesium monitoring.

Missed Dose Advice

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.