Medicine Information

Evo

Eye Drop0.5%Ophthalmic Anti-infectivesATC: S01AE07

Generic Name

Moxifloxacin 0.5% Ophthalmic Solution

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
evo 05 eye drop	৳ 90.00	N/A

Description

Overview of the medicine

Evo-05 Eye Drop contains Moxifloxacin 0.5%, a fourth-generation fluoroquinolone antibiotic used for the treatment of bacterial conjunctivitis and other ocular infections. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication and repair.

Uses & Indications

Bacterial conjunctivitis caused by susceptible organisms

Other superficial ocular bacterial infections (e.g., keratitis, blepharitis)

Dosage

Adults

Instill one drop in the affected eye(s) 3 times a day for 7 days.

Elderly

No dosage adjustment necessary.

Renal_impairment

No dosage adjustment necessary.

How to Take

For ophthalmic use only. Tilt head back, pull down lower eyelid to create a pouch, and instill the drop without touching the eye or eyelid with the dropper tip. Close eye gently for a few seconds. If using other eye drops, wait at least 5 minutes between applications.

Mechanism of Action

Moxifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes necessary for DNA replication, transcription, repair, and recombination. This leads to DNA strand breakage and cell death.

Pharmacokinetics

Onset

Rapid onset of action, typically within minutes for antibacterial effect.

Excretion

Mainly excreted unchanged in urine and feces systemically, but local elimination occurs via tear film and ocular circulation.

Half life

Systemic half-life is around 12 hours, but local ocular half-life is not precisely defined due to minimal systemic absorption.

Absorption

Minimal systemic absorption after ocular administration. Ocular tissue concentrations are achieved effectively.

Metabolism

Minimally metabolized; primarily excreted unchanged.

Side Effects

Contraindications

Hypersensitivity to Moxifloxacin or other quinolones, or to any component of the medication.

Drug Interactions

Systemic Drugs

Minimal systemic absorption, so clinically significant systemic drug interactions are unlikely with ophthalmic use.

Other Ophthalmic Preparations

If using more than one topical ophthalmic drug, administer them at least 5 minutes apart to avoid washout.

Storage

Store at controlled room temperature (20-25°C). Do not freeze. Keep the bottle tightly closed when not in use. Protect from light.

Overdose

Ocular overdose is unlikely to cause systemic toxicity due to minimal systemic absorption. In case of topical overdose, the eye(s) may be flushed with lukewarm water. Systemic overdose is highly unlikely.

Pregnancy & Lactation

Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Caution should be exercised when administered to a nursing mother due to unknown excretion in human milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

5 ml dropper bottle

Shelf Life

Typically 2 years unopened. Once opened, discard after 28 days.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Generic Available

Clinical Trials

Numerous clinical trials have demonstrated the efficacy and safety of Moxifloxacin 0.5% ophthalmic solution for bacterial conjunctivitis, showing high rates of clinical and microbiological cure compared to placebo or other antibiotics.

Lab Monitoring

No specific laboratory monitoring required for ophthalmic use.

Doctor Notes

Ensure correct diagnosis of bacterial conjunctivitis; not effective against viral or fungal infections.
Educate patients on proper administration technique to prevent contamination.
Advise patients on contact lens use during infection.

Patient Guidelines

Do not touch the dropper tip to any surface to avoid contamination.
Remove contact lenses before administration and wait at least 15 minutes before reinserting.
Do not wear contact lenses if you have signs and symptoms of bacterial conjunctivitis.

Missed Dose Advice

If a dose is missed, apply it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.

Driving Precautions

May cause temporary blurred vision or other visual disturbances immediately after administration. Advise patients to wait until vision clears before driving or operating machinery.