Finacof
Generic Name
Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride + Chlorpheniramine Maleate
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| finacof 5 mg syrup | ৳ 70.00 | N/A |
Description
Overview of the medicine
Finacof-5-mg Syrup is a combination medication used to relieve symptoms associated with cough, cold, allergies, and flu, such as dry cough, runny nose, sneezing, and nasal congestion.
Uses & Indications
Dosage
Adults
Adults and children 12 years and over: 10 mL (2 teaspoonfuls) every 4-6 hours, not exceeding 4 doses in 24 hours.
Elderly
Use with caution; dose adjustment may be necessary due to potential for increased sensitivity and reduced renal/hepatic function. Consult a physician.
Renal_impairment
Use with caution; dose reduction may be required due to decreased excretion of metabolites. Consult a physician.
How to Take
Administer orally. Use a measuring spoon or cup to ensure accurate dosage. May be taken with or without food.
Mechanism of Action
Dextromethorphan suppresses cough by acting on the cough center in the medulla. Phenylephrine is a decongestant that constricts blood vessels in the nasal passages, reducing swelling. Chlorpheniramine is an antihistamine that blocks histamine H1 receptors, reducing allergic symptoms like runny nose and sneezing.
Pharmacokinetics
Onset
Cough suppression typically begins within 15-30 minutes for Dextromethorphan. Decongestant and antihistamine effects also occur relatively quickly (within 30-60 minutes).
Excretion
Primarily excreted in the urine as metabolites and unchanged drug.
Half life
Dextromethorphan: 1.4-3.9 hours. Phenylephrine: 2-3 hours. Chlorpheniramine: 20-24 hours.
Absorption
Dextromethorphan is rapidly absorbed from the gastrointestinal tract. Phenylephrine and Chlorpheniramine are also well-absorbed orally.
Metabolism
Dextromethorphan is extensively metabolized in the liver by CYP2D6. Phenylephrine undergoes first-pass metabolism in the gut wall and liver. Chlorpheniramine is metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to any component of the syrup.
- Patients currently taking or who have taken MAO inhibitors within the last 14 days.
- Severe hypertension or coronary artery disease.
- Severe hepatic or renal impairment.
- Narrow-angle glaucoma (due to antihistamine component).
Drug Interactions
MAO Inhibitors
Concurrent use can lead to hypertensive crisis and serotonin syndrome (due to Dextromethorphan).
Antihypertensives
Phenylephrine may reduce the hypotensive effects of antihypertensive medications.
Tricyclic Antidepressants
May enhance the effects of phenylephrine.
CNS Depressants (e.g., alcohol, benzodiazepines)
Increased sedation and central nervous system depression (due to Chlorpheniramine).
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, dizziness, nausea, vomiting, fast heartbeat, high blood pressure, excitation, hallucinations, and convulsions. Management includes supportive care and symptomatic treatment. Naloxone may be considered for severe dextromethorphan overdose.
Pregnancy & Lactation
Use during pregnancy and lactation is generally not recommended unless clearly necessary and advised by a doctor. Consult a healthcare professional before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies, drugstores
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generics available, patent expired for active ingredients.
Clinical Trials
Clinical trials support the efficacy and safety of Dextromethorphan, Phenylephrine, and Chlorpheniramine in relieving cold and cough symptoms when used individually and in combination. Specific trials for 'Finacof-5-mg-syrup' as a brand would be proprietary to the manufacturer.
Lab Monitoring
- None routinely required for typical use.
- Blood pressure monitoring in patients with cardiovascular issues (due to phenylephrine).
Doctor Notes
- Counsel patients on proper dosage and duration of use to avoid misuse and potential side effects.
- Be aware of potential drug interactions, especially with MAO inhibitors and CNS depressants.
- Advise against use in patients with uncontrolled hypertension, severe cardiovascular disease, narrow-angle glaucoma, or severe prostatic hypertrophy.
- Monitor for signs of central nervous system depression, especially in elderly patients.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid operating machinery or driving if experiencing drowsiness or dizziness.
- Consult a doctor if symptoms persist for more than 7 days, worsen, or are accompanied by high fever.
- Do not use in children under 12 years without medical advice.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Get adequate rest.
- Stay hydrated by drinking plenty of fluids.
- Avoid irritants like smoke and dust that may worsen cough.
- Avoid alcohol while taking this medicine.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
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