Medicine Information

Floxy

Name: Floxy
Brand: Floxy
Rating: 4.5 (117 reviews)

Tablet500 mgFluoroquinolone AntibioticATC: J01MA02

Generic Name

Ciprofloxacin

Manufacturer

Popular Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
floxy 500 mg tablet	৳ 15.00	৳ 150.00

Description

Overview of the medicine

Floxy 500 mg Tablet contains Ciprofloxacin, a broad-spectrum fluoroquinolone antibiotic used to treat a wide variety of bacterial infections.

Uses & Indications

Urinary Tract Infections (UTIs)

Respiratory Tract Infections (e.g., exacerbations of chronic bronchitis, pneumonia)

Skin and Soft Tissue Infections

Bone and Joint Infections

Infectious Diarrhea

Typhoid Fever

Gonorrhea

Dosage

Adults

Typically 250 mg to 750 mg orally twice daily, depending on the severity and type of infection. For Floxy 500 mg, common dose is 500 mg twice daily.

Elderly

No specific dose adjustment is needed based on age alone, but renal function should be considered. Use lower end of adult dose range if renal impairment is present.

Renal_impairment

Dose adjustment is necessary. For creatinine clearance 30-60 mL/min, 250-500 mg every 12 hours. For <30 mL/min, 250-500 mg every 18-24 hours.

How to Take

Take orally with or without food. Do not take with dairy products or calcium-fortified juices. Ensure adequate hydration. Swallow the tablet whole with water.

Mechanism of Action

Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA and cell death.

Pharmacokinetics

Onset

Within 1-2 hours for antibacterial action.

Excretion

Primarily excreted unchanged by the kidneys (50-70%) and a smaller portion through feces.

Half life

Approximately 3-5 hours.

Absorption

Well absorbed from the gastrointestinal tract (bioavailability 70-80%). Peak plasma concentrations are achieved 1-2 hours after oral administration.

Metabolism

Partially metabolized in the liver to four active metabolites (less potent than ciprofloxacin).

Side Effects

Contraindications

Hypersensitivity to ciprofloxacin or other fluoroquinolones.
Concomitant administration of tizanidine.
Children and adolescents (except in specific conditions like cystic fibrosis or anthrax exposure).

Drug Interactions

Caffeine

Decreased clearance of caffeine, potentially leading to increased caffeine effects.

Warfarin

Increased anticoagulant effect, monitor INR.

Tizanidine

Contraindicated due to significant increase in tizanidine plasma concentrations, leading to hypotension and somnolence.

Theophylline

Increased plasma levels of theophylline, monitor for toxicity.

Antacids (containing Mg, Al), Iron, Zinc, Sucralfate, Didanosine

Reduced absorption of ciprofloxacin. Administer ciprofloxacin 2 hours before or 6 hours after these agents.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

In the event of acute overdosage, reversible renal toxicity has been reported. Gastric emptying (e.g., vomiting or gastric lavage) may be considered. Maintain adequate hydration. Symptomatic and supportive treatment is recommended. Hemodialysis or peritoneal dialysis remove only a small amount of ciprofloxacin.

Pregnancy & Lactation

Ciprofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk; therefore, caution should be exercised when administering to a nursing mother. Generally not recommended.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 x 10 tablets (blister pack)3 x 10 tablets (blister pack)

Shelf Life

2-3 years from the date of manufacture, refer to package for exact expiry date.

Availability

Available in pharmacies and hospitals

Approval Status

Approved by FDA and DGDA

Patent Status

Generic available, patent expired

WHO Essential Medicine

Yes

Clinical Trials

Ciprofloxacin has undergone extensive clinical trials for its efficacy and safety in various bacterial infections since its introduction. Ongoing research continues to explore its use in specific resistant strains and novel applications.

Lab Monitoring

Renal function tests (creatinine, BUN) in patients with impaired renal function.
Liver function tests (ALT, AST) if signs of hepatic dysfunction occur.
White Blood Cell (WBC) count for prolonged therapy.

Doctor Notes

Counsel patients on the black box warnings, especially regarding tendinitis/tendon rupture, peripheral neuropathy, and CNS effects.
Emphasize completing the full course of therapy to minimize resistance development.
Advise against co-administration with metal-containing antacids, iron, zinc, and dairy products.
Monitor renal function, especially in elderly or renally impaired patients.

Patient Guidelines

Complete the full course of medication, even if symptoms improve, to prevent resistance.
Stay well-hydrated while taking this medicine.
Avoid direct sunlight and use protective clothing or sunscreen, as ciprofloxacin can increase photosensitivity.
Report any joint pain, swelling, or tendon rupture symptoms immediately.
Do not take with antacids, iron, zinc, sucralfate, or dairy products/calcium-fortified juices.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Driving Precautions

Floxy may cause dizziness or visual disturbances. Patients should be advised not to drive or operate machinery if they experience these side effects.

Lifestyle Advice

Maintain good personal hygiene to prevent infections.
Follow a balanced diet and stay physically active.
Avoid excessive caffeine intake, as ciprofloxacin can increase its effects.
Avoid alcohol as it may exacerbate CNS side effects.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Ciprocin (Square Pharmaceuticals Ltd.)Quintor (Beximco Pharmaceuticals Ltd.)Cipro-A (Acme Laboratories Ltd.)Acirox (ACI Limited)Xorim (Renata Limited)