Medicine Information

Fodexil

Name: Fodexil
Brand: Fodexil
Rating: 4.5 (117 reviews)

Tablet1000 mgAntibacterial (Broad-spectrum)ATC: J01MA12

Generic Name

Fodexil Monohydrate

Manufacturer

MediCorp Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
fodexil 1000 mg tablet	৳ 25.00	৳ 150.00

Description

Overview of the medicine

Fodexil 1000 mg Tablet is a broad-spectrum antibiotic belonging to the fluoroquinolone class, primarily used to treat various bacterial infections.

Uses & Indications

Complicated Urinary Tract Infections (UTIs)

Acute Bacterial Exacerbation of Chronic Bronchitis (ABECB)

Community-Acquired Pneumonia (CAP)

Skin and Soft Tissue Infections

Dosage

Adults

1000 mg orally once daily for 7-14 days, depending on the infection type and severity.

Elderly

No specific dose adjustment is required based on age alone, but renal function should be assessed.

Renal_impairment

Dosage reduction is necessary for patients with creatinine clearance < 50 mL/min. Consult product leaflet for specific guidelines.

How to Take

Administer orally, with or without food. Ensure adequate hydration. Avoid taking with dairy products or antacids.

Mechanism of Action

Fodexil inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.

Pharmacokinetics

Onset

Onset of action typically occurs within 1-2 hours after oral administration.

Excretion

Excreted primarily via the kidneys (renal excretion) as unchanged drug and metabolites.

Half life

Plasma half-life ranges from 6 to 8 hours.

Absorption

Rapidly and well absorbed from the gastrointestinal tract. Bioavailability is high.

Metabolism

Undergoes limited hepatic metabolism; primarily excreted as unchanged drug.

Side Effects

Contraindications

Hypersensitivity to fodexil or other fluoroquinolones.
History of tendon disorders related to fluoroquinolone administration.
Epilepsy or other seizure disorders.

Drug Interactions

NSAIDs

Concomitant use with NSAIDs may increase the risk of CNS stimulation and convulsive seizures.

Warfarin

May enhance the anticoagulant effects of warfarin, increasing bleeding risk. INR monitoring is recommended.

Corticosteroids

May increase the risk of tendon rupture when co-administered with fluoroquinolones.

Antacids/Sucralfate/Cations

Can significantly reduce fodexil absorption. Administer fodexil 2 hours before or 6 hours after these agents.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

In case of an overdose, symptoms may include nausea, vomiting, dizziness, confusion, seizures, and prolonged QT interval. Management is symptomatic and supportive. Gastric lavage and activated charcoal may be considered soon after ingestion.

Pregnancy & Lactation

Pregnancy Category C. Not recommended during pregnancy or lactation due to potential risks to fetal cartilage development and excretion into breast milk. Use only if potential benefit outweighs risk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

7 tablets per blister14 tablets per blister

Shelf Life

36 months from manufacturing date.

Availability

Pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Patent Pending

Clinical Trials

Extensive Phase III clinical trials have demonstrated fodexil's efficacy and safety in various bacterial infections, leading to its approval.

Lab Monitoring

Renal function tests (creatinine, BUN)
Liver function tests (ALT, AST, ALP)
Complete blood count (CBC)
INR for patients on warfarin

Doctor Notes

Educate patients thoroughly about the Black Box Warnings, especially regarding tendon rupture and peripheral neuropathy symptoms.
Consider alternative antibiotics if patient has a history of adverse reactions to fluoroquinolones or if tendonopathy risk factors are present.
Monitor renal function, especially in elderly patients, and adjust dose accordingly.

Patient Guidelines

Complete the entire course of medication as prescribed, even if symptoms improve.
Stay well-hydrated by drinking plenty of fluids.
Avoid direct sunlight and use protective clothing/sunscreen due to increased photosensitivity.
Report any unusual pain in joints or muscles, numbness, tingling, or weakness immediately.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Driving Precautions

Fodexil may cause dizziness or visual disturbances. Patients should be advised not to drive or operate machinery if they experience these side effects.

Lifestyle Advice

Avoid strenuous exercise during treatment to minimize the risk of tendon rupture.
Refrain from consuming dairy products or calcium-fortified foods/beverages within 2 hours before or 6 hours after taking fodexil.