Golixen
Generic Name
Fluconazole
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| golixen 150 mg tablet | ৳ 180.00 | ৳ 1,800.00 |
Description
Overview of the medicine
Golixen 150 mg tablet contains Fluconazole, an antifungal medication used to treat a variety of fungal and yeast infections. It is effective against systemic candidiasis, cryptococcal meningitis, and vaginal candidiasis.
Uses & Indications
Dosage
Adults
For vaginal candidiasis: 150 mg as a single oral dose. For oropharyngeal candidiasis: 50-100 mg once daily for 7-14 days. For systemic candidiasis: 400 mg on day 1, then 200-400 mg once daily. Dosage varies significantly based on infection type and severity.
Elderly
No specific dose adjustment is usually required unless there is renal impairment.
Renal_impairment
Dose adjustment required. For creatinine clearance 21-50 mL/min, half the recommended dose. For creatinine clearance <20 mL/min, 25% of the recommended dose.
How to Take
Golixen tablets can be taken with or without food. Swallow the tablet whole with a glass of water.
Mechanism of Action
Fluconazole selectively inhibits fungal cytochrome P450-dependent 14α-lanosterol demethylation, which is an essential step in fungal ergosterol biosynthesis. This inhibition leads to the accumulation of 14α-methyl sterols and a decrease in ergosterol, causing disruption of the fungal cell membrane and cell death.
Pharmacokinetics
Onset
Within 1-2 days for most infections; single dose for vaginal candidiasis may show relief within 24 hours.
Excretion
Primarily excreted unchanged in the urine (approximately 80% of the dose).
Half life
Approximately 30 hours (range 20-50 hours), allowing for once-daily dosing.
Absorption
Well absorbed from the gastrointestinal tract; oral bioavailability is >90%. Peak plasma concentrations occur within 1-2 hours.
Metabolism
Minimally metabolized; approximately 11% of the drug is metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to fluconazole, other azole antifungals, or any component of the formulation.
- Co-administration with terfenadine in patients receiving multiple doses of fluconazole 400 mg/day or higher.
- Co-administration with cisapride, astemizole, pimozide, quinidine, or erythromycin.
Drug Interactions
Warfarin
Increased prothrombin time; monitor INR.
Phenytoin
Increased phenytoin levels; monitor phenytoin concentrations.
Rifampicin
Decreased fluconazole levels; consider increasing fluconazole dose.
Cyclosporine
Increased cyclosporine levels; monitor cyclosporine concentrations.
Hydrochlorothiazide
Increased fluconazole plasma concentrations.
Oral contraceptives
May increase or decrease levels of some oral contraceptive components.
Statins (e.g., atorvastatin)
Increased risk of myopathy and rhabdomyolysis.
Sulfonylureas (e.g., glibenclamide)
Increased plasma concentrations of sulfonylureas, potentially leading to hypoglycemia.
QT-prolonging drugs (e.g., amiodarone)
Increased risk of QT prolongation and torsades de pointes.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include hallucinations and paranoid behavior. Management involves symptomatic treatment and supportive measures. Gastric lavage may be considered. Hemodialysis significantly reduces plasma levels.
Pregnancy & Lactation
Pregnancy: Category D (for prolonged use/high doses). Single dose for vaginal candidiasis is generally considered low risk. Consult a doctor. Lactation: Fluconazole is excreted in breast milk. Use with caution; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture when stored properly.
Availability
Available in pharmacies, hospitals
Approval Status
Approved (for generic Fluconazole)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of fluconazole for various fungal infections.
Lab Monitoring
- Liver function tests (especially during prolonged therapy or in patients with pre-existing liver disease)
- Renal function tests (if dosage adjustment is required)
- Potassium levels (in patients at risk of QT prolongation)
Doctor Notes
- Ensure full patient history, including liver and kidney function, before prescribing.
- Advise patients on potential drug interactions, especially with warfarin and statins.
- Monitor for signs of hepatotoxicity and severe skin reactions.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor, even if your symptoms improve quickly.
- Complete the full course of treatment to prevent the infection from returning.
- Do not share this medicine with others.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or seizures in some individuals. If you experience these side effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent recurrence of fungal infections.
- Wear breathable clothing and avoid tight, synthetic fabrics for skin infections.
- Avoid excessive moisture in affected areas.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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