Goodmet
Generic Name
Metformin Hydrochloride
Manufacturer
ACI Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| goodmet 500 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Goodmet 500 mg Tablet contains Metformin Hydrochloride, an oral antidiabetic drug used to lower blood glucose levels in patients with type 2 diabetes mellitus. It helps the body respond better to the insulin it makes naturally.
Uses & Indications
Dosage
Adults
Initially 500 mg once or twice daily with meals, gradually increasing to a maximum of 2000-2500 mg/day in divided doses. Typical maintenance dose is 500 mg twice daily or 850 mg once daily.
Elderly
Dosage should be individualized based on renal function, starting with lower doses.
Renal_impairment
Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73 m²). Dose adjustment needed for moderate impairment (eGFR 30-60 mL/min/1.73 m²).
How to Take
Take orally with meals to reduce gastrointestinal side effects. Swallow the tablet whole; do not crush or chew.
Mechanism of Action
Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
Pharmacokinetics
Onset
Therapeutic effects are typically observed within days, with maximal effects often seen after several weeks of therapy.
Excretion
Primarily excreted unchanged in the urine by the kidneys.
Half life
Approximately 6.2 hours (plasma elimination half-life), renal elimination half-life is approximately 17.6 hours.
Absorption
Absolute bioavailability of a 500 mg tablet is approximately 50-60%. Food decreases the extent and slightly delays the absorption of Metformin.
Metabolism
Metformin is not metabolized in the liver and is excreted unchanged in the urine.
Side Effects
Contraindications
- Hypersensitivity to Metformin
- Severe renal impairment (eGFR <30 mL/min/1.73 m²)
- Acute or chronic metabolic acidosis (including diabetic ketoacidosis)
- Dehydration, acute heart failure, severe infection, acute myocardial infarction
Drug Interactions
Alcohol
Increases the risk of lactic acidosis, especially in fasting, malnourished, or hepatically impaired patients.
Iodinated contrast agents
Temporarily discontinue metformin at the time of or prior to an iodinated contrast imaging procedure and for 48 hours afterward.
Carbonic anhydrase inhibitors (e.g., topiramate, acetazolamide)
May increase risk of lactic acidosis.
Drugs that reduce metformin clearance (e.g., cimetidine, ranolazine, dolutegravir)
May increase metformin plasma concentrations.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include lactic acidosis, hypoglycemia (less common with monotherapy). Management involves supportive care, hemodialysis (to remove metformin), and correction of acidosis.
Pregnancy & Lactation
Pregnancy: Limited data suggest no increased risk of major birth defects. Benefits of glycemic control outweigh potential risks. Lactation: Metformin is excreted in breast milk; however, amounts are low and generally considered compatible with breastfeeding. Monitor infant for adverse effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established metformin's efficacy and safety in type 2 diabetes, including its cardiovascular benefits (e.g., UKPDS).
Lab Monitoring
- Renal function (eGFR) at baseline and annually (more frequently in elderly or impaired patients)
- Hematologic parameters (e.g., hemoglobin) annually
- Vitamin B12 levels periodically in long-term users
Doctor Notes
- Counsel patients on lactic acidosis symptoms.
- Regularly assess renal function and Vitamin B12 levels.
- Emphasize lifestyle modifications (diet, exercise).
Patient Guidelines
- Take with food as directed by your doctor.
- Do not stop taking without consulting your doctor.
- Report any unusual muscle pain, weakness, or trouble breathing immediately (signs of lactic acidosis).
- Maintain a healthy diet and regular exercise routine.
Missed Dose Advice
If you miss a dose, take it as soon as you remember with your next meal. If it's almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
Goodmet 500 mg Tablet alone does not cause hypoglycemia, so it is unlikely to affect the ability to drive or operate machinery. However, if used in combination with other antidiabetic agents, monitor for signs of hypoglycemia which could impair driving.
Lifestyle Advice
- Follow a balanced diet low in sugar and saturated fats.
- Engage in regular physical activity for at least 30 minutes most days of the week.
- Avoid excessive alcohol consumption.
- Regularly monitor blood glucose levels at home.
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