Medicine Information

Hectamox

Name: Hectamox
Brand: Hectamox
Rating: 4.5 (117 reviews)

Pediatric Drop (Oral Suspension)125 mg/5 mlAntibiotics (Penicillins)ATC: J01CA04

Generic Name

Amoxicillin

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
hectamox 125 mg pediatric drop	৳ 30.00	N/A

Description

Overview of the medicine

Hectamox 125 mg Pediatric Drop is an antibiotic medicine containing Amoxicillin, used to treat a wide range of bacterial infections in children, including respiratory tract infections, ear infections, skin infections, and urinary tract infections. It works by stopping the growth of bacteria.

Uses & Indications

Respiratory tract infections (e.g., tonsillitis, pharyngitis, sinusitis, otitis media)

Skin and soft tissue infections

Urinary tract infections

Gastrointestinal infections (e.g., typhoid and paratyphoid fever)

Dental abscesses

Dosage

Adults

Not typically used in pediatric drop form for adults. Adults usually take higher strength tablets/capsules.

Elderly

Not typically used in pediatric drop form for elderly. Dosage adjustments may be needed based on renal function for higher strength forms.

Renal_impairment

For severe renal impairment (CrCl < 30 mL/min), dosage reduction or extended dosing interval may be necessary. Consult a physician.

How to Take

Administer orally. Shake the bottle well before each use. Use the provided dropper or measuring spoon to ensure accurate dosing. Can be taken with or without food. Complete the full course of treatment as prescribed, even if symptoms improve.

Mechanism of Action

Amoxicillin is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This disrupts the peptidoglycan layer, leading to bacterial cell lysis and death.

Pharmacokinetics

Onset

Antibacterial effects typically begin within 30-60 minutes after administration.

Excretion

Primarily excreted unchanged by the kidneys via glomerular filtration and tubular secretion. About 60-80% of a dose is excreted within 6 hours.

Half life

Approximately 1-1.5 hours in adults with normal renal function; longer in neonates and individuals with renal impairment.

Absorption

Rapidly and well absorbed from the gastrointestinal tract, especially when administered orally. Peak plasma concentrations are achieved within 1-2 hours.

Metabolism

Minimally metabolized; approximately 10-25% is metabolized to inactive penicilloic acid.

Side Effects

Contraindications

Known hypersensitivity to Amoxicillin, any other penicillin, or any component of the formulation
History of severe hypersensitivity reaction to another beta-lactam antibiotic (e.g., cephalosporins)

Drug Interactions

Warfarin

May prolong prothrombin time; monitor INR closely.

Probenecid

Increases amoxicillin plasma levels by decreasing renal tubular secretion.

Methotrexate

Increased methotrexate toxicity due to reduced renal excretion.

Oral contraceptives

May reduce efficacy of oral contraceptives (though clinical significance is debatable).

Storage

Store dry powder below 25°C, protected from moisture. Keep the reconstituted suspension refrigerated (2-8°C). Do not freeze. Keep out of reach of children.

Overdose

Symptoms of overdose may include nausea, vomiting, diarrhea, and rarely, convulsions. Treatment is generally supportive and symptomatic. Gastric lavage or activated charcoal may be considered if ingestion is recent. Hemodialysis can remove amoxicillin from circulation.

Pregnancy & Lactation

Pregnancy Category B. Generally considered safe for use during pregnancy when clearly needed. Small amounts are excreted in breast milk; generally considered compatible with breastfeeding, but monitor infants for diarrhea, candidiasis, or allergic reactions.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

15 ml reconstituted suspension30 ml reconstituted suspension

Shelf Life

Typically 2-3 years for dry powder. Reconstituted suspension has a shelf life of 7-14 days when refrigerated.

Availability

Pharmacies, hospitals, clinics

Approval Status

Approved by regulatory bodies (e.g., FDA, DGDA)

Patent Status

Expired (Generic available)

WHO Essential Medicine

Yes

Clinical Trials

Extensively studied and validated in numerous clinical trials for its efficacy and safety in treating various bacterial infections in pediatric and adult populations. Ongoing surveillance for antibiotic resistance patterns.

Lab Monitoring

Periodically monitor renal, hepatic, and hematopoietic function during prolonged therapy. Monitor for signs of superinfection.

Doctor Notes

Counsel parents/caregivers on the importance of completing the full course to prevent resistance.
Advise on proper reconstitution and administration technique for pediatric drops.
Be vigilant for signs of allergic reactions, especially after the first dose.
Consider potential drug interactions, especially with anticoagulants or methotrexate.

Patient Guidelines

Complete the entire course of medication as prescribed, even if you feel better.
Do not save medication for future illnesses.
Report any severe or persistent side effects to your doctor.
Shake the bottle well before each use.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.