Histason
Generic Name
histason-2-mg-syrup
Manufacturer
Specific Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
histason 2 mg syrup | ৳ 12.00 | N/A |
Description
Overview of the medicine
Histason-2-mg-syrup is an antihistamine medication primarily used to relieve symptoms of seasonal and perennial allergic rhinitis, conjunctivitis, and urticaria. It also has appetite stimulant properties.
Uses & Indications
Dosage
Adults
4 mg 3-4 times daily (10 mL syrup 3-4 times daily); maximum 0.5 mg/kg/day.
Elderly
Lower initial dose recommended, titrate carefully.
Renal_impairment
Adjust dose with caution, starting with lower doses.
How to Take
Oral, with or without food. Use a measuring spoon or cup for accurate dosing.
Mechanism of Action
Cyproheptadine acts as a potent H1-receptor antagonist, blocking the effects of histamine and thereby reducing allergic symptoms. It also exhibits antiserotonergic activity.
Pharmacokinetics
Onset
Starts acting within 15-60 minutes.
Excretion
Mainly excreted in urine, some in feces, as metabolites.
Half life
Approximately 8-16 hours.
Absorption
Well absorbed orally, peak plasma concentrations reached in 6-9 hours.
Metabolism
Extensively metabolized in the liver, primarily by glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to cyproheptadine or other similar drugs
- Newborns or premature infants
- Nursing mothers
- Narrow-angle glaucoma
- Urinary retention (e.g., prostatic hypertrophy)
- Stenosing peptic ulcer
- Pyloroduodenal obstruction
- Concomitant use with MAO inhibitors
Drug Interactions
MAO Inhibitors
May prolong and intensify the anticholinergic effects of antihistamines.
Anticholinergics
Additive anticholinergic effects.
CNS Depressants (alcohol, sedatives, hypnotics, tranquilizers)
Increased sedative effects.
Storage
Store below 30°C in a cool, dry place, away from light and moisture. Do not freeze.
Overdose
Symptoms include drowsiness, coma, convulsions, respiratory depression. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal.
Pregnancy & Lactation
Category B in pregnancy (limited data). Not recommended during lactation as it may inhibit lactation and cause adverse effects in infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
Clinical Trials
Numerous clinical trials have established the efficacy and safety of cyproheptadine for its indicated uses.
Lab Monitoring
- No specific routine lab monitoring required. Liver function tests may be considered in prolonged use or specific conditions.
Doctor Notes
- Counsel patients on potential for drowsiness and advise against driving/operating machinery.
- Monitor for anticholinergic side effects, especially in elderly.
- Consider appetite-stimulating effects for underweight patients, but warn about potential for excessive weight gain.
Patient Guidelines
- Do not drive or operate heavy machinery due to drowsiness.
- Avoid alcohol and other CNS depressants.
- Report any unusual side effects to your doctor.
- Do not stop taking without consulting your doctor.
- Keep out of reach of children.
Missed Dose Advice
Take the missed dose as soon as you remember. If it's near the time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose.
Driving Precautions
This medicine may cause drowsiness and dizziness. Avoid driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Maintain a healthy diet and hydration.
- Get adequate rest, especially if experiencing drowsiness.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
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