Medicine Information

Lagita

Name: Lagita
Brand: Lagita
Rating: 4.5 (117 reviews)

Oral Suspension250 mg/5 mLAntibiotics, FluoroquinolonesATC: J01MA12

Generic Name

lagita-500-mg-suspension

Manufacturer

Unimed Unihealth Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
lagita 500 mg suspension	৳ 125.00	N/A

Description

Overview of the medicine

Levofloxacin is a synthetic broad-spectrum antibacterial agent of the fluoroquinolone class, indicated for the treatment of various bacterial infections.

Uses & Indications

Community-acquired pneumonia

Acute bacterial exacerbation of chronic bronchitis

Acute bacterial sinusitis

Skin and skin structure infections (uncomplicated and complicated)

Urinary tract infections (uncomplicated and complicated), including pyelonephritis

Prostatitis

Dosage

Adults

Typically 500 mg (e.g., 10 mL of 250 mg/5 mL suspension) orally once daily, depending on the infection type and severity. Duration varies from 3 to 14 days.

Elderly

No specific dose adjustment generally needed unless renal impairment is present. Monitor renal function.

Renal_impairment

Dose adjustment required based on creatinine clearance. For CrCl 20-49 mL/min, 250 mg every 24 hours after an initial 500 mg dose. For CrCl 10-19 mL/min, 250 mg every 48 hours after an initial 500 mg dose.

How to Take

Administer orally with or without food. For suspension, shake the bottle well before each use and measure the dose accurately using the provided measuring device.

Mechanism of Action

Levofloxacin exerts its antibacterial activity by inhibiting bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication, transcription, repair, and recombination.

Pharmacokinetics

Onset

Antibacterial effect typically observed within hours of administration.

Excretion

Primarily excreted unchanged in urine by glomerular filtration and tubular secretion, accounting for about 85% of an oral dose.

Half life

Approximately 6-8 hours, allowing for once-daily dosing.

Absorption

Rapid and nearly complete oral absorption. Peak plasma concentrations usually attained within 1-2 hours. Absolute bioavailability approx. 99%.

Metabolism

Minimally metabolized in the liver (less than 5% of dose).

Side Effects

Contraindications

Hypersensitivity to levofloxacin, other fluoroquinolones, or any component of the formulation.
History of tendinitis or tendon rupture associated with fluoroquinolone use.
Children and adolescents (under 18 years of age) due to the risk of joint damage.
Epilepsy or other seizure disorders (relative contraindication).

Drug Interactions

Warfarin

May enhance the anticoagulant effects of warfarin. Monitor Prothrombin Time (PT) / International Normalized Ratio (INR) closely.

Corticosteroids

Concomitant use with corticosteroids increases the risk of severe tendon disorders.

Non-steroidal anti-inflammatory drugs (NSAIDs)

May increase the risk of CNS stimulation and convulsive seizures.

Antacids (magnesium/aluminum), Sucralfate, Iron supplements, Multivitamins (containing zinc)

May significantly reduce levofloxacin absorption. Administer levofloxacin at least 2 hours before or 2 hours after these agents.

Storage

Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.

Overdose

In case of an overdose, gastric lavage may be performed. The patient should be observed and given supportive treatment. Hemodialysis or peritoneal dialysis is not effective in removing levofloxacin from the body.

Pregnancy & Lactation

Pregnancy Category C. Levofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted into human breast milk; caution should be exercised when administered to a nursing mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

100 mL bottle

Shelf Life

24 months (unopened)

Availability

Pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have established the efficacy and safety of levofloxacin for its approved indications, demonstrating its broad-spectrum antibacterial activity and favorable pharmacokinetic profile.

Lab Monitoring

Monitor renal function in patients with known or suspected renal impairment.
Monitor PT/INR in patients receiving concomitant warfarin.
Blood glucose levels in diabetic patients, especially when concurrent use with hypoglycemic agents.

Doctor Notes

Emphasize the Black Box Warning regarding tendinitis, tendon rupture, peripheral neuropathy, CNS effects, and exacerbation of myasthenia gravis to all patients.
Advise patients to immediately discontinue the drug and contact a healthcare professional if they experience symptoms of tendinitis/tendon rupture, peripheral neuropathy, or CNS disturbances.
Exercise caution in patients with a history of QT prolongation, uncorrected hypokalemia, or concomitant use of drugs known to prolong the QT interval.

Patient Guidelines

Complete the full course of medication, even if symptoms improve, to prevent resistance and recurrence.
Avoid excessive exposure to direct sunlight or artificial UV light and use sunscreen, as levofloxacin can cause photosensitivity.
Report any new or worsening joint pain, swelling, numbness, tingling, or weakness immediately to your doctor.
Shake the suspension bottle well before each use and measure the dose accurately.

Missed Dose Advice

If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

May cause dizziness, lightheadedness, or visual disturbances. Patients should assess their reaction to the drug before driving or operating machinery.

Lifestyle Advice

Maintain good hydration by drinking plenty of fluids.
Avoid alcohol as it may worsen CNS side effects like dizziness and confusion.

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