Medicine Information

Lamidin

Name: Lamidin
Brand: Lamidin
Rating: 4.5 (117 reviews)

Tablet100 mgAntiretroviral, Nucleoside Reverse Transcriptase Inhibitor (NRTI)ATC: J05AF05

Generic Name

Lamivudine 100 mg Tablet

Manufacturer

Fictional Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
lamidin 100 mg tablet	৳ 25.30	৳ 253.00

Description

Overview of the medicine

Lamidin 100 mg Tablet contains Lamivudine, an antiviral medication used to treat chronic Hepatitis B virus (HBV) infection. It works by interfering with the replication of the virus.

Uses & Indications

Treatment of chronic Hepatitis B virus (HBV) infection in adults and children (≥ 2 years of age) with evidence of viral replication and active liver inflammation.

Dosage

Adults

For chronic Hepatitis B: 100 mg once daily.

Elderly

No specific dose adjustment is required in elderly patients, but renal function should be monitored.

Renal_impairment

Dose adjustment is required in patients with creatinine clearance <50 mL/min. For CrCl 30-49 mL/min: 50 mg once daily; for CrCl 15-29 mL/min: 25 mg once daily; for CrCl 5-14 mL/min: 25 mg first dose, then 25 mg every other day; for CrCl <5 mL/min: 25 mg first dose, then 25 mg every 3-7 days.

How to Take

Lamidin 100 mg Tablet should be taken orally, with or without food. It is important to take the medication regularly at the same time each day.

Mechanism of Action

Lamivudine is a nucleoside analogue. It is intracellularly phosphorylated to its active triphosphate form. Lamivudine triphosphate inhibits viral reverse transcriptase by competing with the natural substrate deoxycytidine triphosphate and by incorporation into viral DNA, resulting in DNA chain termination.

Pharmacokinetics

Onset

Within hours for antiviral effect, clinical improvements seen over weeks to months.

Excretion

Mainly excreted unchanged in the urine (approximately 70% of the dose) by glomerular filtration and active tubular secretion.

Half life

Plasma elimination half-life is 5-7 hours.

Absorption

Rapidly absorbed after oral administration; bioavailability is approximately 80-86%. Peak plasma concentrations occur 0.5-1.5 hours post-dose.

Metabolism

Not extensively metabolized. Primarily eliminated unchanged.

Side Effects

Contraindications

Hypersensitivity to lamivudine or any component of the formulation.

Drug Interactions

Emtricitabine

Should not be used concurrently due to similar mechanism of action and potential for additive toxicities.

Trimethoprim/Sulfamethoxazole

Increases lamivudine plasma concentrations; may require dose adjustment.

Storage

Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.

Overdose

Limited experience with acute overdose. In studies, high doses caused no unexpected adverse effects. Treatment should be symptomatic and supportive.

Pregnancy & Lactation

Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk; advise mothers not to breastfeed if being treated with lamivudine for HBV.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 tablets in a blister pack

Shelf Life

24-36 months

Availability

Available in pharmacies and hospitals nationwide

Approval Status

Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)

Patent Status

Generally off-patent in many countries

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of Lamivudine in chronic Hepatitis B patients, showing significant reduction in HBV DNA levels and improvement in liver histology.

Lab Monitoring

Liver function tests (ALT, AST, bilirubin)
Renal function (creatinine, CrCl)
HBV DNA levels (viral load)
HBeAg/anti-HBe status
Complete blood count (CBC)

Doctor Notes

Emphasize strict adherence to the dosing schedule to prevent resistance and viral rebound.
Monitor liver function tests, renal function, and HBV viral load regularly.
Counsel patients on the importance of not discontinuing the medication without medical advice.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Do not stop taking the medicine without consulting your doctor, as this can lead to severe exacerbation of Hepatitis B.
Inform your doctor about all other medications you are taking.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Driving Precautions

Lamivudine is generally not expected to impair the ability to drive or operate machinery. However, if you experience side effects like dizziness or fatigue, avoid such activities.