Lesterol
Generic Name
Atorvastatin
Manufacturer
MediCorp Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lesterol 20 mg capsule | ৳ 12.05 | ৳ 120.50 |
Description
Overview of the medicine
Lesterol 20 mg Capsule contains Atorvastatin, a medication used to lower cholesterol and triglycerides in the blood. It helps prevent heart attacks, strokes, and other heart-related problems.
Uses & Indications
Dosage
Adults
Initial dose 10-20 mg once daily. Max 80 mg daily. Dosage should be individualized based on LDL-C levels.
Elderly
No dosage adjustment needed, but use with caution.
Renal_impairment
No dosage adjustment needed.
How to Take
Take orally once daily, with or without food, at any time of day, preferably in the evening.
Mechanism of Action
Atorvastatin is a selective, competitive inhibitor of HMG-CoA reductase, the enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis. It decreases hepatic cholesterol synthesis and increases the number of LDL receptors on the hepatocyte surface, enhancing LDL uptake and catabolism.
Pharmacokinetics
Onset
Lipid-lowering effects begin within 2 weeks, maximal effect in 2-4 weeks.
Excretion
Primarily excreted in bile following hepatic metabolism. Less than 2% is excreted in urine.
Half life
Approximately 14 hours (due to active metabolites, half-life of HMG-CoA reductase inhibitory activity is 20-30 hours).
Absorption
Rapidly absorbed, peak plasma concentrations reached within 1-2 hours.
Metabolism
Extensively metabolized by cytochrome P450 3A4 (CYP3A4) to active and inactive metabolites.
Side Effects
Contraindications
- Active liver disease or unexplained persistent elevations of serum transaminases
- Pregnancy and lactation
- Hypersensitivity to atorvastatin or any component of the formulation
Drug Interactions
Warfarin
May enhance anticoagulant effect.
Cyclosporine, Gemfibrozil, Niacin
Increased risk of myopathy/rhabdomyolysis.
Clarithromycin, Itraconazole, Protease inhibitors
Increased plasma concentrations of atorvastatin.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Treatment should be symptomatic and supportive. Hemodialysis is unlikely to significantly enhance atorvastatin clearance.
Pregnancy & Lactation
Contraindicated during pregnancy and breastfeeding due to potential fetal harm and excretion in breast milk. Women of childbearing potential should use adequate contraception.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in all pharmacies and hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Generic available (Patent expired)
WHO Essential Medicine
YesClinical Trials
Extensively studied in various clinical trials (e.g., ASCOT-LLA, MIRACL, TNT) demonstrating significant reductions in cardiovascular events across diverse patient populations.
Lab Monitoring
- Liver function tests (LFTs) before initiation and periodically during treatment
- Lipid panel (total cholesterol, LDL-C, HDL-C, triglycerides) to monitor efficacy
Doctor Notes
- Emphasize adherence to diet and exercise alongside medication.
- Monitor LFTs and lipid profile regularly.
- Educate patients on symptoms of myopathy.
Patient Guidelines
- Follow a cholesterol-lowering diet
- Report any unexplained muscle pain, tenderness, or weakness immediately
- Avoid grapefruit juice while on this medication
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose. Do not double the dose to catch up.
Driving Precautions
Lesterol is unlikely to affect ability to drive or operate machinery. However, if you experience dizziness, avoid driving.
Lifestyle Advice
- Maintain a healthy diet and exercise regimen
- Limit alcohol intake
- Quit smoking
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
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