Medicine Information

Levamdocal

Name: Levamdocal
Brand: Levamdocal
Rating: 4.5 (117 reviews)

Tablet125 mgNon-steroidal Anti-inflammatory Drug (NSAID)ATC: M01AE99

Generic Name

Levamdocal 125 mg Tablet

Manufacturer

Medix Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
levamdocal 125 mg tablet	৳ 4.00	৳ 60.00

Description

Overview of the medicine

Levamdocal 125 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It is typically prescribed for conditions such as arthritis, musculoskeletal pain, and dysmenorrhea.

Uses & Indications

Rheumatoid Arthritis

Osteoarthritis

Ankylosing Spondylitis

Acute Gout

Post-operative pain

Musculoskeletal disorders (e.g., sprains, strains)

Dysmenorrhea

Dosage

Adults

Oral: 125 mg once or twice daily, or as directed by physician. Maximum daily dose should not exceed 250 mg.

Elderly

A lower initial dose (e.g., 125 mg once daily) may be considered, with careful monitoring for adverse effects, especially renal and gastrointestinal.

Renal_impairment

Use with caution. Dosage reduction may be necessary in patients with moderate to severe renal impairment (CrCl <30 mL/min). Avoid in severe renal failure.

How to Take

Take the tablet whole with a glass of water, preferably with food or milk to minimize gastrointestinal discomfort. Do not crush or chew.

Mechanism of Action

Levamdocal works by inhibiting the activity of cyclooxygenase (COX) enzymes, primarily COX-2, which are responsible for the synthesis of prostaglandins. Prostaglandins are mediators of pain, inflammation, and fever.

Pharmacokinetics

Onset

Pain relief typically starts within 30-60 minutes.

Excretion

Mainly excreted in urine (about 60-70%) as metabolites, with some excretion in feces (about 30-40%).

Half life

Approximately 6-8 hours.

Absorption

Rapidly and well absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are usually reached within 1-2 hours.

Metabolism

Extensively metabolized in the liver, primarily via cytochrome P450 enzymes (e.g., CYP2C9), to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to Levamdocal or any NSAIDs (e.g., aspirin, ibuprofen)
History of gastrointestinal bleeding or peptic ulcer disease
Severe renal or hepatic impairment
Severe heart failure
Third trimester of pregnancy
Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)

Drug Interactions

Lithium

Increased plasma lithium levels, leading to toxicity.

Methotrexate

Increased methotrexate toxicity.

Corticosteroids

Increased risk of gastrointestinal ulceration and bleeding.

ACE Inhibitors/ARBs

Reduced antihypertensive effect, increased risk of renal impairment.

Diuretics (e.g., Furosemide)

Reduced diuretic and antihypertensive effects, increased risk of renal impairment.

Anticoagulants (e.g., Warfarin)

Increased risk of bleeding.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. In severe cases, acute renal failure, coma, and convulsions may occur. Treatment is symptomatic and supportive. Gastric lavage or activated charcoal may be considered if ingested recently.

Pregnancy & Lactation

Pregnancy Category C in early pregnancy, changing to Category D in the third trimester (due to risk of premature closure of the fetal ductus arteriosus). Should be avoided in the third trimester. Use with caution during lactation; small amounts may pass into breast milk, consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 Tablets30 Tablets (3x10's)

Shelf Life

36 months from manufacturing date.

Availability

Pharmacies, hospitals, clinics

Approval Status

Approved by regulatory authorities (hypothetical)

Patent Status

Patent Pending

Clinical Trials

Ongoing phase III trials for long-term safety and efficacy in chronic pain management. Initial studies showed comparable efficacy to established NSAIDs with a favorable GI tolerability profile.

Lab Monitoring

Regular monitoring of renal function (serum creatinine, BUN)
Liver function tests (ALT, AST)
Complete blood count (CBC) for signs of anemia or blood dyscrasias
Blood pressure monitoring

Doctor Notes

Advise patients on the importance of adhering to prescribed doses and reporting any adverse effects promptly.
Consider proton pump inhibitor co-administration in patients at high risk of GI complications.

Patient Guidelines

Follow your doctor's instructions regarding dosage and duration.
Take with food or milk to reduce stomach upset.
Do not exceed the recommended dose.
Inform your doctor about all other medications you are taking.
Report any unusual bleeding, stomach pain, or black stools immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Driving Precautions

May cause dizziness or blurred vision in some individuals. If these symptoms occur, avoid driving or operating heavy machinery.

Lifestyle Advice

Avoid alcohol consumption while taking this medicine.
Maintain adequate hydration.
For chronic pain, consider physical therapy and exercise as advised by your doctor.