Medicine Information

Magadrate Plus

Name: Magadrate Plus
Brand: Magadrate Plus
Rating: 4.5 (117 reviews)

Oral SuspensionMagaldrate 400 mg/5 ml + Simethicone 20 mg/5 mlAntacids & AntiflatulentsATC: A02AF02

Generic Name

Magaldrate + Simethicone (Magaldrate 400 mg)

Manufacturer

General Pharmaceutical Company

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
magadrate plus 400 mg suspension	৳ 50.00	N/A

Description

Overview of the medicine

Magaldrate Plus 400 mg Suspension is an antacid and antiflatulent medication used to relieve symptoms of heartburn, indigestion, and gas. It contains Magaldrate, which neutralizes stomach acid, and Simethicone, which helps break down gas bubbles.

Uses & Indications

Heartburn

Indigestion

Acid reflux

Sour stomach

Bloating and gas associated with hyperacidity

Dosage

Adults

10 ml (2 teaspoonfuls) 3-4 times daily, between meals and at bedtime, or as directed by a physician.

Elderly

Same as adult dosage, consult physician if other medications are taken.

Renal_impairment

Use with caution in severe renal impairment due to potential accumulation of magnesium and aluminum. Consult a physician.

How to Take

Shake well before use. Take orally between meals and at bedtime. Do not exceed recommended dosage.

Mechanism of Action

Magaldrate reacts with stomach acid to form a neutral salt, increasing gastric pH and reducing pepsin activity. Simethicone acts as an antifoaming agent, reducing surface tension of gas bubbles in the gastrointestinal tract, allowing them to coalesce and be easily expelled.

Pharmacokinetics

Onset

Within 15 minutes

Excretion

Excreted in feces

Half life

Not applicable (local action, minimal systemic absorption)

Absorption

Magaldrate has minimal systemic absorption. Simethicone is not absorbed systemically.

Metabolism

Not applicable (local action, minimal systemic absorption)

Side Effects

Contraindications

Hypersensitivity to Magaldrate, Simethicone, or any component
Severe renal impairment (due to magnesium/aluminum accumulation risk)

Drug Interactions

Iron preparations

Antacids may reduce iron absorption. Take iron supplements several hours before or after antacids.

Thyroid hormones (e.g., Levothyroxine)

Reduced absorption of thyroid hormones. Separate administration by several hours.

Tetracyclines & Quinolones (e.g., Ciprofloxacin)

Antacids can decrease the absorption of these antibiotics. Administer 2-4 hours apart.

Storage

Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children.

Overdose

Overdose may lead to gastrointestinal upset (diarrhea, constipation) and, in severe cases of renal impairment, hypermagnesemia or aluminum toxicity. Treatment is supportive and symptomatic.

Pregnancy & Lactation

Generally considered safe for use during pregnancy and lactation when used as directed, but consult a physician or pharmacist before use.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

100 ml bottle200 ml bottle

Shelf Life

Typically 24-36 months from manufacturing date.

Availability

Pharmacies nationwide

Approval Status

Approved in Bangladesh

Patent Status

Off-patent

Clinical Trials

Well-established active ingredients, extensive historical clinical data supporting efficacy and safety for symptomatic relief of acidity and gas.

Lab Monitoring

Electrolyte levels (especially magnesium and phosphate) in patients with renal impairment or prolonged high-dose use.

Doctor Notes

Advise patients about potential drug interactions, especially with antibiotics and iron supplements.
Counsel on lifestyle modifications for GERD/dyspepsia.
Monitor renal function in prolonged use or high-risk patients.

Patient Guidelines

Shake the bottle well before each use.
Do not take more than the recommended dose.
Consult your doctor if symptoms persist for more than 2 weeks.
Separate administration from other medications by 2-4 hours.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Driving Precautions

This medicine is unlikely to affect your ability to drive or operate machinery.

Lifestyle Advice

Avoid trigger foods like spicy or fatty foods, caffeine, and alcohol.
Eat smaller, more frequent meals.
Do not lie down immediately after eating.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Antacid Plus (Square Pharmaceuticals Ltd.)Gaviscon Liquid (Reckitt Benckiser)Algin Plus (Drug International Ltd.)

Global Brand Names

International brand names for this medicine

MediCorp Pharma Ltd.

Injection5 mg

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