Medicine Information

Meditrim

Name: Meditrim
Brand: Meditrim
Rating: 4.5 (117 reviews)

SuspensionTrimethoprim 40 mg + Sulfamethoxazole 200 mg per 5 mLAnti-bacterial (Sulfonamides & Trimethoprim)ATC: J01EE01

Generic Name

Co-trimoxazole (Trimethoprim + Sulfamethoxazole) Suspension

Manufacturer

Global Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
meditrim 200 mg suspension	৳ 20.00	N/A

Description

Overview of the medicine

Meditrim 200 mg Suspension is a combination antibiotic containing Trimethoprim and Sulfamethoxazole, used to treat various bacterial infections.

Uses & Indications

Urinary Tract Infections (UTIs)

Respiratory Tract Infections (e.g., acute exacerbations of chronic bronchitis, Pneumocystis jirovecii pneumonia - PCP)

Otitis Media

Gastrointestinal Infections (e.g., traveler's diarrhea)

Nocardiosis

Dosage

Adults

Standard adult dosage for suspension is usually 20 mL (160 mg TMP/800 mg SMX) every 12 hours. Dosage varies based on infection severity and indication.

Elderly

Dosage adjustment may be necessary in elderly patients, especially those with renal impairment. Close monitoring is advised.

Renal_impairment

Significant dosage reduction or increased dosing interval is required. Contraindicated in severe renal impairment.

How to Take

Administer orally, preferably with food or milk to minimize gastrointestinal upset. Shake well before use. Use a measuring device for accurate dosing.

Mechanism of Action

Co-trimoxazole inhibits two sequential steps in the bacterial folic acid synthesis pathway, leading to synergistic bactericidal action.

Pharmacokinetics

Onset

Antibacterial effect typically observed within 1-4 hours after administration.

Excretion

Mainly excreted by the kidneys, primarily through glomerular filtration and tubular secretion.

Half life

Trimethoprim: approximately 8-11 hours; Sulfamethoxazole: approximately 10-12 hours.

Absorption

Both trimethoprim and sulfamethoxazole are rapidly and well absorbed from the gastrointestinal tract after oral administration.

Metabolism

Primarily metabolized in the liver, with both components undergoing various metabolic transformations.

Side Effects

Contraindications

Hypersensitivity to sulfamethoxazole, trimethoprim, or any excipients
Severe renal or hepatic impairment
Porphyria
Megaloblastic anemia due to folate deficiency
Infants younger than 2 months of age

Drug Interactions

Warfarin

May enhance anticoagulant effect, increasing bleeding risk.

Phenytoin

May increase phenytoin levels, requiring dose adjustment.

Methotrexate

May increase methotrexate toxicity due to impaired renal excretion.

Oral hypoglycemics (sulfonylureas)

Potentiate hypoglycemic effect.

ACE inhibitors and Potassium-sparing diuretics

Increased risk of hyperkalemia.

Storage

Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.

Overdose

Symptoms include nausea, vomiting, dizziness, headache, confusion, and bone marrow depression. Management is supportive, including gastric lavage, forced diuresis, and acidification of urine. Folinic acid may be given to counteract trimethoprim's effects on folate metabolism.

Pregnancy & Lactation

Pregnancy Category D. Avoid in the first trimester due to potential teratogenicity and near term due to risk of kernicterus in the neonate. Use with caution during lactation; small amounts are excreted in breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

50 mL bottle100 mL bottle

Shelf Life

Typically 2-3 years for unopened bottles. Refer to product label for specific expiry date. Once opened, use within a specified period (e.g., 28 days).

Availability

Available in pharmacies worldwide

Approval Status

Approved by major regulatory bodies

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Co-trimoxazole has been extensively studied since its introduction, with numerous clinical trials validating its efficacy and safety for various bacterial infections.

Lab Monitoring

Complete Blood Count (CBC) with differential, especially during prolonged treatment
Renal function tests (BUN, creatinine)
Liver function tests (ALT, AST)
Serum potassium levels, particularly in elderly patients or those with renal impairment

Doctor Notes

Monitor complete blood count, renal function, and serum potassium regularly, especially in elderly or renally impaired patients, and during prolonged therapy.
Consider folate supplementation in patients at risk of folate deficiency or receiving high-dose/prolonged treatment.
Educate patients on symptoms of hypersensitivity reactions and the importance of immediate discontinuation if such symptoms occur.

Patient Guidelines

Complete the full course of medication, even if symptoms improve, to prevent recurrence and resistance.
Drink plenty of water to prevent crystallization in the urine.
Avoid excessive sun exposure and use sunscreen due to photosensitivity.
Report any severe skin rash, yellowing of skin/eyes, or unusual bleeding/bruising immediately.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

This medicine may cause dizziness or blurred vision in some individuals. Patients should be cautious when driving or operating machinery until they know how it affects them.