Motiwin

Clinical Trials

Numerous clinical trials have established the efficacy and safety of domperidone in treating nausea, vomiting, and dyspepsia. Recent trials have focused on cardiac safety, particularly QTc prolongation risks at higher doses.

Lab Monitoring

• ECG monitoring (especially in patients with cardiac risk factors or on interacting drugs)
• Electrolyte levels (Potassium, Magnesium)
• Renal function tests if prolonged use in impaired patients

Doctor Notes

• Assess patient's cardiac risk factors (e.g., QTc prolongation, underlying heart disease, electrolyte imbalance) before prescribing.
• Prescribe the lowest effective dose for the shortest duration.
• Avoid concomitant use with strong CYP3A4 inhibitors or other QTc prolonging drugs.

Patient Guidelines

• Take 15-30 minutes before meals.
• Shake the suspension well before each use.
• Do not exceed the recommended dose.
• Report any signs of unusual heartbeats or dizziness to your doctor immediately.
• Do not take with grapefruit juice.
• Store in a cool, dry place away from direct sunlight.

Missed Dose Advice

If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose to catch up.

Driving Precautions

May cause drowsiness or dizziness. Patients should be cautioned against driving or operating machinery until they know how Motiwin affects them.

Lifestyle Advice

• Avoid fatty foods that can exacerbate indigestion.
• Eat smaller, more frequent meals.
• Avoid lying down immediately after eating.