Adults

Typically 250-500 mg every 8 hours, or 500-875 mg every 12 hours, depending on severity and infection site. This suspension strength is primarily for children.

Elderly

Dosage adjustments may be necessary based on renal function.

Renal_impairment

Dose reduction or increased dosing interval is required. For CrCl <30 mL/min, dosage adjustment is crucial.

Onset

Typically within 30-60 minutes

Excretion

Primarily excreted unchanged by the kidneys, through both glomerular filtration and tubular secretion. Significant amounts excreted in urine.

Half life

Approximately 1 to 1.5 hours in adults with normal renal function

Absorption

Rapidly and well absorbed from the gastrointestinal tract, especially when given orally. Food does not significantly affect absorption.

Metabolism

Partially metabolized in the liver to inactive metabolites. About 10-25% of the dose is metabolized.

Probenecid

Increases amoxicillin levels by decreasing renal tubular secretion.

Allopurinol

Increased incidence of rash, especially in hyperuricemic patients.

Methotrexate

Reduced excretion of methotrexate, increasing toxicity.

Oral contraceptives

May reduce efficacy of oral contraceptives (use additional birth control).

Oral anticoagulants (e.g., Warfarin)

May prolong prothrombin time; monitor INR.