Napa
Generic Name
Paracetamol
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| napa 125 mg suppository | ৳ 4.00 | N/A |
Description
Overview of the medicine
Napa 125 mg Suppository contains Paracetamol, an analgesic and antipyretic, used to relieve fever and mild to moderate pain, especially in children who cannot take oral medication.
Uses & Indications
Dosage
Adults
Not typically used for adults; adult dose is usually higher (e.g., 500-1000 mg oral).
Elderly
Not applicable for this strength. Consult physician for appropriate dosage if paracetamol is needed.
Renal_impairment
Use with caution; dose adjustment may be necessary in severe renal impairment (consult physician).
How to Take
For rectal administration only. Insert the suppository gently into the rectum, pointed end first. Ensure hands are clean before and after use.
Mechanism of Action
Paracetamol is thought to act primarily in the central nervous system by inhibiting prostaglandin synthesis, which is responsible for pain and fever.
Pharmacokinetics
Onset
Fever reduction typically within 30-60 minutes, pain relief within 30 minutes.
Excretion
Excreted mainly in the urine as glucuronide and sulfate conjugates.
Half life
Approximately 1-4 hours in adults, slightly shorter in children.
Absorption
Well absorbed from the rectum, with peak plasma concentrations occurring within 1-2 hours.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation, with a small amount processed by cytochrome P450 into a toxic intermediate (NAPQI) which is detoxified by glutathione.
Side Effects
Contraindications
- •Hypersensitivity to paracetamol or any component of the suppository.
- •Severe hepatic impairment or active liver disease.
- •Recent rectal surgery or inflammation of the rectum (proctitis).
Drug Interactions
Warfarin
May increase the anticoagulant effect of warfarin with prolonged, regular use, increasing bleeding risk.
Other Paracetamol-containing products
Avoid concomitant use with other paracetamol-containing medicines to prevent overdose.
Enzyme inducers (e.g., carbamazepine, phenobarbital)
May increase the risk of paracetamol hepatotoxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Do not freeze.
Overdose
Symptoms include nausea, vomiting, abdominal pain, and liver damage. Immediate medical attention is crucial. Treatment includes activated charcoal and N-acetylcysteine (NAC).
Pregnancy & Lactation
Paracetamol is generally considered safe for use during pregnancy and lactation at therapeutic doses, but always consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals, Clinics
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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