Napa
Generic Name
Paracetamol
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| napa 500 mg tablet | ৳ 1.20 | ৳ 12.00 |
Description
Overview of the medicine
Napa 500 mg Tablet contains Paracetamol, an analgesic and antipyretic used to relieve mild to moderate pain and reduce fever. It is widely used for conditions like headache, toothache, muscle pain, and cold/flu symptoms.
Uses & Indications
Dosage
Adults
500 mg to 1000 mg (1-2 tablets) every 4-6 hours as needed, not exceeding 4000 mg (8 tablets) in 24 hours.
Elderly
Similar to adult dosage; however, caution is advised with hepatic or renal impairment due to potential accumulation.
Renal_impairment
Dosage interval prolongation may be necessary depending on creatinine clearance (e.g., 500 mg every 6-8 hours for moderate impairment).
How to Take
Take orally with water, with or without food. If stomach upset occurs, take with food. Tablets can be crushed if difficulty swallowing.
Mechanism of Action
Paracetamol is thought to act primarily in the central nervous system by inhibiting cyclooxygenase (COX) enzymes, particularly COX-2, which are involved in prostaglandin synthesis. This action increases the pain threshold. It also acts on the hypothalamic heat-regulating center to produce antipyresis (fever reduction).
Pharmacokinetics
Onset
30-60 minutes for analgesia, 30 minutes for antipyresis.
Excretion
Excreted mainly in the urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
1.25 to 3 hours, prolonged in liver disease or overdose.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 30-60 minutes after oral administration.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation, with a small amount metabolized by the cytochrome P450 enzyme system to a highly reactive intermediate (NAPQI).
Side Effects
Contraindications
- •Hypersensitivity to Paracetamol or any component of the formulation.
- •Severe hepatic impairment or active liver disease.
Drug Interactions
Alcohol
Chronic excessive alcohol consumption increases the risk of hepatotoxicity with Paracetamol.
Warfarin
Chronic use of Paracetamol may potentiate the anticoagulant effect of warfarin, increasing the risk of bleeding.
Cholestyramine
May reduce the absorption of Paracetamol if administered within one hour.
Metoclopramide/Domperidone
May increase the rate of absorption of Paracetamol.
Storage
Store in a cool, dry place, below 30°C (86°F). Protect from light, heat, and moisture. Keep out of reach and sight of children.
Overdose
Overdose of Paracetamol can cause severe, sometimes fatal, liver damage (hepatotoxicity). Symptoms may include nausea, vomiting, abdominal pain, anorexia, and malaise. Seek immediate medical attention or contact a poison control center if an overdose is suspected. Antidote (N-acetylcysteine) should be administered as soon as possible.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and breastfeeding at recommended therapeutic doses. However, it is always advisable to consult a healthcare professional before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture. Refer to the packaging for the exact expiry date.
Availability
Pharmacies, drugstores, supermarkets
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Patent expired
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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