Medicine Information

Preba

Name: Preba
Brand: Preba
Rating: 4.5 (117 reviews)

Capsule50 mgAnticonvulsants; Anxiolytics, OtherATC: N03AX16

Generic Name

Pregabalin

Manufacturer

Incepta Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
preba 50 mg capsule	৳ 13.00	৳ 130.00

Description

Overview of the medicine

Preba 50 mg capsule contains Pregabalin, an anticonvulsant and neuropathic pain agent. It is used to treat various conditions including neuropathic pain, fibromyalgia, and as an adjunctive therapy for partial onset seizures in adults.

Uses & Indications

Neuropathic pain (diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury)

Fibromyalgia

Adjunctive therapy for partial onset seizures in adults

Generalized anxiety disorder (GAD)

Dosage

Adults

Initial dose 50 mg three times daily (150 mg/day), may be increased to 100 mg three times daily (300 mg/day) within 1 week. Maximum recommended dose 600 mg/day.

Elderly

Dose adjustment may be necessary in elderly patients due to potential for decreased renal function.

Renal_impairment

Dosage must be reduced in patients with impaired renal function. Consult prescribing information for specific guidelines.

How to Take

Oral administration, with or without food. Swallow the capsule whole with water.

Mechanism of Action

Pregabalin binds with high affinity to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This binding modulates the release of several excitatory neurotransmitters, including glutamate, norepinephrine, and substance P, leading to its anticonvulsant and analgesic effects.

Pharmacokinetics

Onset

Within 1 week for neuropathic pain; varies for other indications.

Excretion

Primarily excreted unchanged in urine.

Half life

Approximately 6.3 hours.

Absorption

Rapidly absorbed after oral administration. Peak plasma concentrations are reached within 1.5 hours.

Metabolism

Negligible metabolism in humans; approximately 98% excreted unchanged in urine.

Side Effects

Contraindications

Hypersensitivity to pregabalin or any component of the formulation

Drug Interactions

ACE inhibitors

Potential for increased peripheral edema.

Opioids, Benzodiazepines, Alcohol

Increased CNS depression and respiratory depression.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms include somnolence, confusion, agitation, and rarely coma. Treatment is supportive; hemodialysis may be effective.

Pregnancy & Lactation

Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in human milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules30 capsules

Shelf Life

Typically 24-36 months from manufacturing date.

Availability

Available in pharmacies nationwide

Approval Status

Approved by major regulatory bodies (e.g., FDA, DGDA)

Patent Status

Generic available (original patent expired)

Clinical Trials

Extensive clinical trials have demonstrated efficacy in neuropathic pain, fibromyalgia, and as adjunctive therapy for partial seizures. Ongoing research explores other potential uses and long-term safety.

Lab Monitoring

Monitor renal function (especially in elderly or renally impaired patients)

Doctor Notes

Advise patients about potential for dizziness and somnolence, especially at initiation.
Emphasize gradual dose reduction to minimize withdrawal symptoms.
Monitor for signs of misuse or abuse in susceptible patients.

Patient Guidelines

Do not stop taking this medicine suddenly without consulting your doctor, as it may cause withdrawal symptoms.
Avoid driving or operating heavy machinery until you know how this medicine affects you.
Report any mood changes, suicidal thoughts, or unusual behavior to your doctor immediately.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose.