Medicine Information

Precodil

Name: Precodil
Brand: Precodil

Oral Suspension5 mg/5 mL (1 mg/mL)Systemic CorticosteroidsATC: H02AB06

Generic Name

Prednisolone Oral Suspension

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
precodil 1 suspension	৳ 100.00	N/A

Description

Overview of the medicine

Prednisolone is a synthetic corticosteroid drug used for its anti-inflammatory and immunosuppressant effects. It is used to treat a wide range of conditions, including allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, or breathing disorders.

Uses & Indications

Allergic disorders (e.g., severe asthma, allergic rhinitis, drug hypersensitivity reactions)

Rheumatic disorders (e.g., rheumatoid arthritis, systemic lupus erythematosus)

Dermatologic diseases (e.g., severe psoriasis, eczema, pemphigus)

Respiratory diseases (e.g., chronic obstructive pulmonary disease, sarcoidosis)

Gastrointestinal diseases (e.g., Crohn's disease, ulcerative colitis)

Hematologic disorders (e.g., hemolytic anemia, thrombocytopenia)

Neoplastic diseases (for palliative management of leukemias and lymphomas)

Dosage

Adults

Dosage is highly individualized and depends on the disease being treated and the patient's response. Typical initial daily doses range from 5 mg to 60 mg, usually given in divided doses.

Elderly

No specific dose adjustments are usually required, but caution should be exercised due to increased risk of side effects in elderly patients.

Renal_impairment

No dose adjustment is generally required for renal impairment, but careful monitoring is advised.

How to Take

Take orally, usually with food or milk to minimize gastrointestinal upset. Shake the suspension well before each use. Use a calibrated measuring device for accurate dosing.

Mechanism of Action

Prednisolone works by binding to intracellular glucocorticoid receptors, which then translocate to the nucleus and modulate gene expression. This leads to the synthesis of anti-inflammatory proteins and inhibition of pro-inflammatory mediators, thereby reducing inflammation and suppressing immune responses.

Pharmacokinetics

Onset

Anti-inflammatory effects typically begin within hours, but full therapeutic effect may take days.

Excretion

Excreted mainly in the urine as inactive metabolites and, to a lesser extent, as unchanged drug.

Half life

Elimination half-life is 2-4 hours; biological half-life is 18-36 hours.

Absorption

Rapidly and well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 1-2 hours after oral administration.

Metabolism

Primarily metabolized in the liver to inactive metabolites, including conjugation with glucuronic acid and sulfate.

Side Effects

Contraindications

Systemic fungal infections
Known hypersensitivity to prednisolone or any component of the formulation

Drug Interactions

Anticoagulants (e.g., Warfarin)

Prednisolone may either potentiate or inhibit the effects of anticoagulants; careful monitoring of INR is required.

Diuretics (e.g., Thiazides, Loop diuretics)

Concurrent use may enhance potassium depletion.

NSAIDs (Nonsteroidal Anti-inflammatory Drugs)

Increased risk of gastrointestinal bleeding and ulceration.

Antidiabetic agents (e.g., Insulin, Oral hypoglycemics)

Prednisolone may increase blood glucose levels, requiring adjustment of antidiabetic medication dosage.

CYP3A4 Inducers (e.g., Rifampin, Phenytoin, Barbiturates)

May decrease prednisolone plasma concentrations, potentially reducing its therapeutic effects.

Storage

Store at room temperature (20-25°C or 68-77°F). Protect from light, moisture, and freezing. Keep out of reach of children.

Overdose

Acute overdose with corticosteroids is generally not life-threatening. Symptoms may include fluid retention, hypertension, hyperglycemia, and potassium loss. Treatment is supportive and symptomatic; no specific antidote is available. Long-term overdose can lead to Cushingoid features and adrenal suppression.

Pregnancy & Lactation

Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in human milk; caution is advised when administered to a nursing mother. Monitor the infant for adrenal suppression.

Side Effects

Contraindications

Systemic fungal infections
Known hypersensitivity to prednisolone or any component of the formulation

Drug Interactions

Anticoagulants (e.g., Warfarin)

Prednisolone may either potentiate or inhibit the effects of anticoagulants; careful monitoring of INR is required.

Diuretics (e.g., Thiazides, Loop diuretics)

Concurrent use may enhance potassium depletion.

NSAIDs (Nonsteroidal Anti-inflammatory Drugs)

Increased risk of gastrointestinal bleeding and ulceration.

Antidiabetic agents (e.g., Insulin, Oral hypoglycemics)

Prednisolone may increase blood glucose levels, requiring adjustment of antidiabetic medication dosage.

CYP3A4 Inducers (e.g., Rifampin, Phenytoin, Barbiturates)

May decrease prednisolone plasma concentrations, potentially reducing its therapeutic effects.

Storage

Store at room temperature (20-25°C or 68-77°F). Protect from light, moisture, and freezing. Keep out of reach of children.

Overdose

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

60 mL bottle100 mL bottle

Shelf Life

Typically 2-3 years when unopened, refer to the manufacturer's specific expiry date on the packaging.

Availability

Available in pharmacies and hospitals

Approval Status

Approved by major regulatory bodies (e.g., FDA, DGDA)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Prednisolone has undergone extensive clinical trials over decades, establishing its efficacy and safety for various inflammatory and autoimmune conditions. Ongoing research continues to optimize its use and minimize side effects.

Lab Monitoring

Blood glucose levels (especially in diabetic or pre-diabetic patients)
Electrolyte levels (particularly potassium)
Blood pressure monitoring
Bone mineral density (for long-term therapy)
Ophthalmic examinations (for long-term therapy)

Doctor Notes

Emphasize the importance of gradual tapering to prevent adrenal crisis.
Educate patients on potential side effects, particularly increased susceptibility to infections and metabolic changes.
Consider bone-protective measures (e.g., calcium/vitamin D supplementation, bisphosphonates) for long-term users.
Monitor growth in pediatric patients and ocular pressure in patients on prolonged therapy.

Patient Guidelines

Do not stop taking this medicine abruptly, especially after long-term use, as it can lead to serious withdrawal symptoms. Always follow your doctor's instructions for tapering the dose.
Take this medicine with food or milk to reduce stomach upset.
Report any unusual side effects or signs of infection (e.g., fever, sore throat) to your doctor immediately.
Carry identification stating you are on corticosteroid therapy, especially in case of an emergency.

Missed Dose Advice

If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

This medicine may cause dizziness or vision changes in some individuals. If you experience these effects, avoid driving or operating machinery.

Lifestyle Advice

Maintain a balanced diet rich in calcium and vitamin D to support bone health, especially during long-term therapy.
Limit sodium intake to manage fluid retention and blood pressure.
Engage in regular, moderate exercise if tolerated.