Precodil
Generic Name
Prednisolone
Manufacturer
Hypothetical Pharma Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| precodil 20 mg tablet | ৳ 6.28 | ৳ 62.80 |
Description
Overview of the medicine
Precodil 20 mg Tablet contains Prednisolone, a synthetic corticosteroid. It is widely used for its anti-inflammatory and immunosuppressive effects to treat a broad range of conditions including allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, and breathing disorders.
Uses & Indications
Dosage
Adults
Dosage is highly individualized. Typically, initial doses range from 5-60 mg daily, adjusted based on the condition, patient response, and severity. Doses can be taken once daily in the morning or in divided doses. Tapering is crucial for long-term use.
Elderly
Lower initial doses may be considered due to increased susceptibility to side effects. Close monitoring for adverse effects like osteoporosis, hypertension, and diabetes is recommended.
Renal_impairment
No specific dosage adjustment is usually required for mild to moderate renal impairment. Use with caution in severe renal impairment, monitoring for fluid retention.
How to Take
Take orally, preferably with or immediately after food or milk to minimize gastrointestinal irritation. Swallow the tablet whole with water. Do not crush, chew, or break. Do not stop taking this medicine abruptly.
Mechanism of Action
Prednisolone works by binding to glucocorticoid receptors in the cytoplasm, forming a complex that translocates to the nucleus. There, it modulates gene expression, inhibiting the synthesis of inflammatory mediators like prostaglandins and leukotrienes, and suppressing immune responses.
Pharmacokinetics
Onset
Anti-inflammatory effects can be seen within 1-2 hours, but full therapeutic effect may take longer.
Excretion
Mainly excreted in the urine as inactive metabolites and a small amount of unchanged drug.
Half life
Plasma half-life: 2-3 hours; Biological half-life: 18-36 hours.
Absorption
Well absorbed orally, peak plasma concentrations typically achieved within 1-2 hours.
Metabolism
Primarily hepatic, converted to inactive metabolites, mainly via CYP3A4 enzymes.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to prednisolone or any component of the tablet
- Administration of live or live-attenuated vaccines during high-dose corticosteroid therapy
Drug Interactions
Antidiabetic agents
May increase blood glucose levels, requiring adjustment of antidiabetic medication.
NSAIDs (e.g., Ibuprofen)
Increased risk of gastrointestinal ulcers and bleeding.
Diuretics (e.g., Furosemide)
Increased risk of hypokalemia.
Anticoagulants (e.g., Warfarin)
Altered anticoagulant effect; requires INR monitoring.
CYP3A4 inducers (e.g., Phenytoin, Rifampicin)
May decrease prednisolone levels and efficacy.
CYP3A4 inhibitors (e.g., Ketoconazole, Erythromycin)
May increase prednisolone levels and risk of side effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose with prednisolone is rare and usually does not cause life-threatening symptoms. Chronic overdose can lead to severe side effects such as Cushing's syndrome, adrenal suppression, and other corticosteroid-related adverse events. Management is supportive and symptomatic, with gradual withdrawal of the drug.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in breast milk and may cause adverse effects in nursing infants; use with caution or consider alternatives during lactation.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to prednisolone or any component of the tablet
- Administration of live or live-attenuated vaccines during high-dose corticosteroid therapy
Drug Interactions
Antidiabetic agents
May increase blood glucose levels, requiring adjustment of antidiabetic medication.
NSAIDs (e.g., Ibuprofen)
Increased risk of gastrointestinal ulcers and bleeding.
Diuretics (e.g., Furosemide)
Increased risk of hypokalemia.
Anticoagulants (e.g., Warfarin)
Altered anticoagulant effect; requires INR monitoring.
CYP3A4 inducers (e.g., Phenytoin, Rifampicin)
May decrease prednisolone levels and efficacy.
CYP3A4 inhibitors (e.g., Ketoconazole, Erythromycin)
May increase prednisolone levels and risk of side effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose with prednisolone is rare and usually does not cause life-threatening symptoms. Chronic overdose can lead to severe side effects such as Cushing's syndrome, adrenal suppression, and other corticosteroid-related adverse events. Management is supportive and symptomatic, with gradual withdrawal of the drug.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in breast milk and may cause adverse effects in nursing infants; use with caution or consider alternatives during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory bodies (e.g., DGDA, FDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Prednisolone has been extensively studied in numerous clinical trials over decades for its various approved indications, demonstrating efficacy and informing safety profiles across a wide range of conditions.
Lab Monitoring
- Blood glucose levels (especially in diabetic patients)
- Electrolyte levels (e.g., potassium)
- Blood pressure monitoring
- Bone mineral density scans (for long-term use)
- Ophthalmological exams (for long-term use, to check for glaucoma/cataracts)
- Growth monitoring in children
Doctor Notes
- Always emphasize the importance of gradual dose tapering to patients, especially after prolonged therapy, to prevent adrenal insufficiency.
- Monitor patients for signs of infection, especially those on immunosuppressive doses.
- Consider calcium and vitamin D supplementation for patients on long-term corticosteroid therapy to mitigate osteoporosis risk.
- Regularly assess blood pressure, blood glucose, and electrolyte levels.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor; do not alter the dose or stop without consulting them.
- Report any signs of infection (fever, sore throat) immediately, especially if you feel unwell.
- Do not receive any vaccinations without consulting your doctor while on this medication.
- Wear a medical alert tag if on long-term corticosteroid therapy.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Prednisolone may cause dizziness, vertigo, or visual disturbances in some individuals. If you experience these symptoms, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D, and low in sodium to counter potential side effects.
- Engage in regular, moderate exercise to help maintain bone density and muscle strength, if appropriate and advised by your doctor.
- Limit alcohol consumption.
- Avoid exposure to people with contagious diseases, especially chickenpox or measles, if you are immunosuppressed.
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