Precodil
Generic Name
Prednisolone
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| precodil 5 mg oral solution | ৳ 65.19 | N/A |
Description
Overview of the medicine
Precodil 5 mg Oral Solution contains Prednisolone, a synthetic corticosteroid used to treat a wide range of inflammatory and autoimmune conditions. It works by reducing inflammation and suppressing the immune system.
Uses & Indications
Dosage
Adults
Dosage varies greatly depending on the condition being treated. Typical initial daily doses range from 5 mg to 60 mg, which should be gradually tapered after control is achieved. Administer orally, preferably with food to minimize gastrointestinal upset.
Elderly
No specific dose adjustment is generally required, but caution should be exercised due to increased susceptibility to adverse effects and potential comorbidities. Start with the lowest effective dose.
Renal_impairment
No specific dose adjustment is usually necessary for renal impairment, but careful monitoring is advised.
How to Take
Take Precodil 5 mg Oral Solution orally, usually once daily in the morning or as directed by your doctor. It can be taken with food or milk to minimize stomach upset. Shake the bottle well before each use. Measure the dose accurately using a measuring device.
Mechanism of Action
Prednisolone binds to intracellular glucocorticoid receptors, forming a steroid-receptor complex that translocates to the nucleus and modulates gene expression. This leads to anti-inflammatory, immunosuppressive, and antiproliferative effects by inhibiting the release of inflammatory mediators and altering immune cell function.
Pharmacokinetics
Onset
Approximately 1-2 hours (oral)
Excretion
Excreted mainly in the urine as metabolites, with a small amount of unchanged drug.
Half life
Plasma elimination half-life is 2-4 hours, but the biological half-life is 18-36 hours due to strong receptor binding.
Absorption
Rapidly and well absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are achieved within 1-2 hours.
Metabolism
Primarily metabolized in the liver to inactive metabolites and to a minor extent to active prednisolone by 11β-hydroxysteroid dehydrogenase type 1.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to prednisolone or any component of the formulation
- Live vaccines administration (during high-dose therapy)
Drug Interactions
Anticoagulants (e.g., Warfarin)
Corticosteroids may alter the effects of anticoagulants; close monitoring of INR is recommended.
Phenobarbital, Rifampin, Phenytoin
These drugs can increase the metabolism of prednisolone, reducing its therapeutic effect. Dose adjustment of prednisolone may be necessary.
Insulin and oral hypoglycemic agents
Prednisolone may increase blood glucose levels, requiring adjustment of antidiabetic medication doses.
Diuretics (e.g., Thiazide, Loop diuretics)
May enhance potassium depletion, increasing the risk of hypokalemia.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Concurrent use may increase the risk of gastrointestinal ulceration and bleeding.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose with prednisolone is rare. Symptoms may include exaggerated side effects like fluid retention, hypertension, and hyperglycemia. Treatment is primarily supportive and symptomatic; no specific antidote is available. Long-term overdose can lead to Cushing's syndrome.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in breast milk; caution should be exercised when administered to a nursing woman. Infants exposed to corticosteroids in breast milk should be monitored for signs of adrenal suppression.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to prednisolone or any component of the formulation
- Live vaccines administration (during high-dose therapy)
Drug Interactions
Anticoagulants (e.g., Warfarin)
Corticosteroids may alter the effects of anticoagulants; close monitoring of INR is recommended.
Phenobarbital, Rifampin, Phenytoin
These drugs can increase the metabolism of prednisolone, reducing its therapeutic effect. Dose adjustment of prednisolone may be necessary.
Insulin and oral hypoglycemic agents
Prednisolone may increase blood glucose levels, requiring adjustment of antidiabetic medication doses.
Diuretics (e.g., Thiazide, Loop diuretics)
May enhance potassium depletion, increasing the risk of hypokalemia.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Concurrent use may increase the risk of gastrointestinal ulceration and bleeding.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose with prednisolone is rare. Symptoms may include exaggerated side effects like fluid retention, hypertension, and hyperglycemia. Treatment is primarily supportive and symptomatic; no specific antidote is available. Long-term overdose can lead to Cushing's syndrome.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in breast milk; caution should be exercised when administered to a nursing woman. Infants exposed to corticosteroids in breast milk should be monitored for signs of adrenal suppression.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months when stored unopened under recommended conditions. Refer to the product packaging for the exact expiry date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Prednisolone, as a widely used corticosteroid, has been extensively studied for decades. Its efficacy and safety are supported by numerous historical and ongoing clinical trials across a broad range of inflammatory and autoimmune conditions. Modern clinical trials often focus on specific patient populations, long-term outcomes, or comparisons with newer therapeutic agents.
Lab Monitoring
- Blood glucose levels (especially in diabetic patients)
- Electrolyte levels (e.g., potassium)
- Blood pressure monitoring
- Bone mineral density (for long-term therapy)
- Adrenal function tests (after withdrawal of long-term therapy)
Doctor Notes
- Emphasize the importance of gradual tapering of prednisolone to prevent adrenal insufficiency and withdrawal symptoms. Provide a clear tapering schedule to the patient.
- Monitor patients on long-term therapy for signs of osteoporosis, diabetes, hypertension, and cataracts/glaucoma. Consider prophylactic measures like calcium and vitamin D supplementation.
- Counsel patients on the importance of reporting any signs of infection promptly, given the immunosuppressive effects.
- Inform patients about potential mood changes and advise them to report severe psychological disturbances.
Patient Guidelines
- Always take this medicine exactly as prescribed by your doctor. Do not stop taking it suddenly, as this can lead to withdrawal symptoms and adrenal insufficiency. Your doctor will advise you on how to gradually reduce the dose.
- Take with food or milk to reduce stomach upset.
- Inform your doctor or dentist if you are taking prednisolone before any surgery or dental procedure.
- Avoid close contact with people who have infections like chickenpox or measles, as your immune system may be weakened.
- Carry a steroid card if you are on long-term therapy, detailing your dosage and condition.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Precodil 5 mg Oral Solution generally does not affect the ability to drive or operate machinery. However, if you experience side effects like dizziness, blurred vision, or mood changes, avoid driving or operating machinery until these symptoms subside.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D (e.g., milk, yogurt, leafy greens) to support bone health, especially during long-term use.
- Engage in regular, moderate exercise to help maintain muscle strength and bone density.
- Limit salt intake to reduce fluid retention and high blood pressure.
- Avoid alcohol as it can further irritate the stomach lining.
- Get adequate rest and manage stress to support overall well-being.
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