Medicine Information

Precodil

Name: Precodil
Brand: Precodil

Tablet5 mgCorticosteroids, GlucocorticoidsATC: H02AB06

Generic Name

Prednisolone

Manufacturer

Incepta Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
precodil 5 mg tablet	৳ 1.72	৳ 68.80

Description

Overview of the medicine

Precodil 5 mg Tablet contains Prednisolone, a synthetic corticosteroid. It is primarily used for its potent anti-inflammatory and immunosuppressive properties to treat a wide range of conditions.

Uses & Indications

Allergic reactions (e.g., severe asthma, dermatitis)

Inflammatory conditions (e.g., rheumatoid arthritis, lupus, inflammatory bowel disease)

Autoimmune disorders

Certain cancers (e.g., leukemia, lymphoma)

Organ transplant rejection prophylaxis

Dosage

Adults

Dosage varies widely based on the condition being treated and individual response. Typically, 5-60 mg daily in single or divided doses. Tapering is crucial for long-term use.

Elderly

Lower doses may be required due to increased sensitivity and potential for renal/hepatic impairment. Careful monitoring is advised.

Renal_impairment

No specific dose adjustment is generally required for mild to moderate renal impairment, but caution and monitoring are recommended for severe cases.

How to Take

Take Precodil tablets orally with food or milk to minimize gastrointestinal upset. Swallow whole with water, do not chew or crush. Follow your doctor's instructions exactly.

Mechanism of Action

Prednisolone works by binding to glucocorticoid receptors in cells, altering gene expression. This leads to the inhibition of various inflammatory mediators and suppression of immune responses, thereby reducing inflammation and preventing tissue damage.

Pharmacokinetics

Onset

Anti-inflammatory effects typically begin within 1-2 hours, but full therapeutic effect may take longer.

Excretion

Excreted mainly in the urine as metabolites and unconjugated prednisolone.

Half life

Plasma half-life is 2-3 hours; biological half-life is 18-36 hours.

Absorption

Rapidly and well absorbed from the gastrointestinal tract, reaching peak plasma concentrations within 1-2 hours.

Metabolism

Primarily metabolized in the liver to inactive metabolites (e.g., prednisolone 20-beta-dihydro) and conjugated forms.

Side Effects

Contraindications

Systemic fungal infections (unless specific antifungal therapy is being used)
Known hypersensitivity to prednisolone or any component of the formulation

Drug Interactions

Warfarin

Prednisolone may alter the anticoagulant effect of warfarin (increase or decrease INR); monitor INR closely.

Live vaccines

Avoid live vaccines due to immunosuppressive effects.

NSAIDs (e.g., ibuprofen)

Increased risk of gastrointestinal ulcers and bleeding.

Diuretics (e.g., furosemide)

Increased risk of hypokalemia (low potassium).

Antidiabetic agents (e.g., insulin)

Prednisolone may increase blood glucose levels, requiring adjustment of antidiabetic medication.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Acute overdose is rarely life-threatening. Chronic overdose can lead to symptoms of Cushing's syndrome (e.g., moon face, buffalo hump, thinning skin). Management includes supportive and symptomatic treatment, gradual withdrawal of the drug.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in breast milk; caution is advised when administering to a nursing mother. Consult your doctor.

Side Effects

Contraindications

Systemic fungal infections (unless specific antifungal therapy is being used)
Known hypersensitivity to prednisolone or any component of the formulation

Drug Interactions

Warfarin

Prednisolone may alter the anticoagulant effect of warfarin (increase or decrease INR); monitor INR closely.

Live vaccines

Avoid live vaccines due to immunosuppressive effects.

NSAIDs (e.g., ibuprofen)

Increased risk of gastrointestinal ulcers and bleeding.

Diuretics (e.g., furosemide)

Increased risk of hypokalemia (low potassium).

Antidiabetic agents (e.g., insulin)

Prednisolone may increase blood glucose levels, requiring adjustment of antidiabetic medication.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

3 x 10 tablets

Shelf Life

24-36 months (check specific product packaging)

Availability

Available in pharmacies and hospitals nationwide

Approval Status

Approved (DGDA)

Patent Status

Off-patent, generic available

WHO Essential Medicine

Yes

Clinical Trials

Prednisolone has been extensively studied in numerous clinical trials for its efficacy and safety across a wide range of indications. Its use is well-established in medical practice.

Lab Monitoring

Blood glucose levels (especially in diabetic patients)
Electrolyte levels (e.g., potassium)
Blood pressure monitoring
Bone mineral density (for long-term use)
Ophthalmic examinations (for long-term use)

Doctor Notes

Emphasize gradual tapering of prednisolone dosage to prevent adrenal crisis, especially after prolonged therapy.
Monitor patients for signs of infection, hyperglycemia, hypertension, and osteoporosis during treatment.
Educate patients on potential side effects and the importance of adherence to the prescribed regimen.

Patient Guidelines

Do not stop taking this medicine abruptly, especially after long-term use, as it can lead to withdrawal symptoms. Follow your doctor's instructions for tapering the dose.
Take Precodil with food or milk to minimize stomach upset.
Report any unusual side effects or worsening of your condition to your doctor immediately.
Inform your doctor or dentist that you are taking this medicine before any surgery or dental procedure.
Avoid close contact with people who have infections, especially chickenpox or measles, as your immune system may be suppressed.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Prednisolone may cause mood changes, blurred vision, or dizziness in some individuals. If you experience these effects, avoid driving or operating machinery.

Lifestyle Advice

Maintain a balanced diet, potentially low in sodium and high in potassium, calcium, and vitamin D.
Engage in regular weight-bearing exercise to help maintain bone density, under medical advice.
Avoid excessive alcohol consumption and smoking.
Practice good hygiene to reduce infection risk.