Precodil
Generic Name
Prednisolone
Manufacturer
Various Generic Manufacturers
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| precodil 10 mg tablet | ৳ 3.24 | ৳ 32.40 |
Description
Overview of the medicine
Prednisolone is a synthetic glucocorticoid that effectively acts as an anti-inflammatory and immunosuppressive agent. It is used to treat a wide range of inflammatory and autoimmune conditions.
Uses & Indications
Dosage
Adults
Dosage varies widely depending on the condition being treated, ranging from 5 mg to 60 mg daily. It should be individualized and taken with food to minimize gastrointestinal upset. Doses should be tapered gradually when discontinuing prolonged therapy.
Elderly
Elderly patients should be started on the lowest effective dose due to increased risk of side effects. Careful monitoring is advised.
Renal_impairment
Generally, no dose adjustment is required in renal impairment, but caution is advised in severe cases. Hepatic impairment may require dose reduction.
How to Take
Take the tablet orally, usually once daily, preferably in the morning with food or milk to reduce gastric irritation. Do not chew or crush the tablet unless specified.
Mechanism of Action
Prednisolone binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene expression. This leads to the inhibition of inflammatory mediators and suppression of immune responses.
Pharmacokinetics
Onset
Anti-inflammatory effects typically begin within 1-2 hours, but clinical improvement may take longer.
Excretion
Excreted mainly in the urine, predominantly as inactive metabolites.
Half life
Plasma half-life is 2-4 hours, but biological half-life (duration of action) is 18-36 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract following oral administration.
Metabolism
Primarily metabolized in the liver, mainly by 11-beta-hydroxysteroid dehydrogenase, to inactive metabolites.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to prednisolone or any components of the formulation
- Administration of live or live-attenuated vaccines during high-dose corticosteroid therapy
Drug Interactions
Warfarin
May alter anticoagulant effects; monitor INR.
Live vaccines
Avoid during high-dose corticosteroid therapy due to immunosuppression.
Insulin and oral hypoglycemics
May increase blood glucose levels, requiring adjustment of antidiabetic medication.
Phenytoin, Barbiturates, Rifampicin
May decrease corticosteroid effects due to increased metabolism.
Diuretics (especially potassium-depleting)
May enhance potassium loss, increasing risk of hypokalemia.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of gastrointestinal ulceration and bleeding.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare and usually does not lead to life-threatening reactions. Long-term overdose can lead to symptoms of Cushing's syndrome (e.g., moon face, fluid retention). Management is symptomatic and supportive; reduce the dose or gradually withdraw the drug under medical supervision.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in breast milk; advise caution, and monitor the infant for adverse effects.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to prednisolone or any components of the formulation
- Administration of live or live-attenuated vaccines during high-dose corticosteroid therapy
Drug Interactions
Warfarin
May alter anticoagulant effects; monitor INR.
Live vaccines
Avoid during high-dose corticosteroid therapy due to immunosuppression.
Insulin and oral hypoglycemics
May increase blood glucose levels, requiring adjustment of antidiabetic medication.
Phenytoin, Barbiturates, Rifampicin
May decrease corticosteroid effects due to increased metabolism.
Diuretics (especially potassium-depleting)
May enhance potassium loss, increasing risk of hypokalemia.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of gastrointestinal ulceration and bleeding.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare and usually does not lead to life-threatening reactions. Long-term overdose can lead to symptoms of Cushing's syndrome (e.g., moon face, fluid retention). Management is symptomatic and supportive; reduce the dose or gradually withdraw the drug under medical supervision.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in breast milk; advise caution, and monitor the infant for adverse effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 2-3 years from the date of manufacture, specific details on packaging.
Availability
Available in pharmacies, hospitals and clinics
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Prednisolone has been extensively studied in numerous clinical trials across various indications over several decades, establishing its efficacy and safety profile. Ongoing research explores new applications and formulations.
Lab Monitoring
- Blood glucose (especially in diabetic or pre-diabetic patients)
- Electrolytes (e.g., potassium)
- Bone mineral density (for long-term therapy)
- Eye examinations (for long-term therapy to detect cataracts/glaucoma)
- Growth monitoring in pediatric patients
Doctor Notes
- Emphasize the importance of gradual tapering when discontinuing treatment to prevent adrenal crisis.
- Monitor blood pressure, blood glucose, and bone mineral density in patients on long-term therapy.
- Educate patients on symptoms of infection and the need for prompt medical attention.
- Consider calcium and vitamin D supplementation for patients on prolonged corticosteroid therapy.
Patient Guidelines
- Take exactly as prescribed by your doctor and do not stop abruptly without medical advice.
- Take with food or milk to minimize stomach upset.
- Report any unusual side effects or signs of infection immediately.
- Avoid close contact with people who have infections (e.g., chickenpox, measles) as your immunity may be lowered.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause dizziness or changes in vision in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D (especially for long-term users).
- Engage in regular, moderate exercise to maintain muscle strength and bone health.
- Avoid excessive alcohol consumption.
- Manage stress effectively.
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