Precodil
Generic Name
Dexamethasone 15 mg Oral Solution
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| precodil 15 mg oral solution | ৳ 80.55 | N/A |
Description
Overview of the medicine
Precodil Oral Solution contains Dexamethasone, a potent synthetic corticosteroid with anti-inflammatory and immunosuppressive properties. It is used to treat a wide range of conditions including allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, and breathing disorders.
Uses & Indications
Dosage
Adults
Dosage varies widely based on the condition being treated and patient response. Typically ranges from 0.5 mg to 10 mg daily in single or divided doses. For specific conditions, higher doses may be used temporarily.
Elderly
No specific dose adjustments are usually necessary, but caution should be exercised due to increased susceptibility to adverse effects.
Renal_impairment
No dose adjustment is generally required for renal impairment, but careful monitoring is advised.
How to Take
Take the oral solution as directed by your doctor. It can be taken with food or milk to minimize stomach upset. Use the provided measuring device for accurate dosing. Do not stop taking it abruptly without consulting your doctor.
Mechanism of Action
Dexamethasone works by binding to specific glucocorticoid receptors in the cytoplasm of cells, forming a complex that translocates into the nucleus. This complex then modulates gene expression, leading to the synthesis of anti-inflammatory proteins and inhibition of pro-inflammatory mediators, thereby reducing inflammation and suppressing immune responses.
Pharmacokinetics
Onset
Within hours for systemic effects, peak effects may take longer.
Excretion
Excreted mainly in the urine as inactive metabolites.
Half life
Plasma half-life: 1.8-3.5 hours; Biological half-life: 36-54 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract.
Metabolism
Primarily metabolized in the liver by CYP3A4 enzymes.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to dexamethasone or any component of the formulation
- Administration of live or live attenuated vaccines in patients receiving immunosuppressive doses of corticosteroids
Drug Interactions
Warfarin
May alter anticoagulant effects; monitor INR.
Diuretics (e.g., Thiazides, Loop diuretics)
Increased risk of hypokalemia.
CYP3A4 Inducers (e.g., Phenytoin, Rifampicin)
May decrease dexamethasone efficacy.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of gastrointestinal ulceration.
CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir)
May increase dexamethasone levels and effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms of acute overdose are rare and usually include exaggeration of known side effects such as fluid retention, electrolyte imbalance, and hyperglycemia. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Dexamethasone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk and may cause adverse effects in nursing infants; therefore, caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to dexamethasone or any component of the formulation
- Administration of live or live attenuated vaccines in patients receiving immunosuppressive doses of corticosteroids
Drug Interactions
Warfarin
May alter anticoagulant effects; monitor INR.
Diuretics (e.g., Thiazides, Loop diuretics)
Increased risk of hypokalemia.
CYP3A4 Inducers (e.g., Phenytoin, Rifampicin)
May decrease dexamethasone efficacy.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of gastrointestinal ulceration.
CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir)
May increase dexamethasone levels and effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms of acute overdose are rare and usually include exaggeration of known side effects such as fluid retention, electrolyte imbalance, and hyperglycemia. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Dexamethasone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk and may cause adverse effects in nursing infants; therefore, caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture. Refer to the product packaging for specific expiry date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Dexamethasone has been extensively studied in numerous clinical trials for its efficacy in a wide range of conditions, including its role in COVID-19 treatment. Ongoing research continues to explore new applications and optimal dosing strategies.
Lab Monitoring
- Blood glucose levels (especially in diabetic patients)
- Electrolyte levels (particularly potassium)
- Blood pressure monitoring
- Bone mineral density (with long-term use)
- Growth monitoring in children
Doctor Notes
- Educate patients on the importance of gradual withdrawal to prevent adrenal insufficiency.
- Monitor for signs of infection, hyperglycemia, and electrolyte imbalances during therapy.
- Consider bone-protective measures for patients on long-term corticosteroid therapy.
Patient Guidelines
- Take exactly as prescribed by your doctor and do not stop abruptly.
- Report any unusual side effects or worsening of your condition.
- Avoid close contact with people who have infections (e.g., chickenpox, measles) as your immune system may be suppressed.
- Carry an identification card stating that you are on corticosteroid therapy.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Dexamethasone may cause dizziness, vision changes, or mood disturbances in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet rich in calcium and vitamin D.
- Engage in regular, moderate exercise to support bone health.
- Limit salt intake to help manage fluid retention and blood pressure.
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