Precodil
Generic Name
Flupentixol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| precodil 2 mg tablet | ৳ 0.75 | ৳ 15.00 |
Description
Overview of the medicine
Precodil 2 mg Tablet contains Flupentixol, a thioxanthene derivative antipsychotic medication. It is primarily used for the treatment of schizophrenia and other psychoses. In lower doses, it can also be used for depressive states with apathy or anergia, and chronic anxiety.
Uses & Indications
Dosage
Adults
For psychoses: Initially 3-9 mg daily in divided doses, increasing to 18 mg daily if needed. For depressive states/anxiety: 0.5 mg to 3 mg daily.
Elderly
Lower doses are typically recommended, usually half the adult dose. Close monitoring for side effects is advised.
Renal_impairment
Generally no dose adjustment required, but caution is advised in severe renal impairment.
How to Take
Take orally with or without food. Swallow the tablet whole with water. Do not crush or chew it.
Mechanism of Action
Flupentixol acts as a dopamine receptor antagonist, primarily blocking D1 and D2 dopamine receptors in the brain. It also possesses some alpha-1 adrenergic and serotonin 5-HT2 receptor blocking activity, contributing to its antipsychotic, antidepressant, and anxiolytic effects.
Pharmacokinetics
Onset
Antipsychotic effects may take several days to weeks to fully manifest. Antidepressant effects typically within a few days.
Excretion
Mainly excreted via feces (biliary excretion) and to a lesser extent via urine.
Half life
Approximately 35 hours (oral formulation).
Absorption
Well absorbed orally, peak plasma concentrations reached in 3-8 hours.
Metabolism
Extensively metabolized in the liver, primarily via sulfoxidation, N-dealkylation, and glucuronidation.
Side Effects
Contraindications
- Acute alcohol, barbiturate or opioid intoxication
- Circulatory collapse
- Depressed level of consciousness
- Severe central nervous system (CNS) depression
- Phaeochromocytoma
- Bone marrow depression
- Blood dyscrasias
- Hypersensitivity to flupentixol or other thioxanthenes
Drug Interactions
Antihypertensives
Potentiates the hypotensive effect, leading to orthostatic hypotension.
Anticholinergic drugs
Potentiation of anticholinergic effects.
Drugs that prolong QT interval
Increased risk of QT prolongation and ventricular arrhythmias.
Dopamine agonists (e.g., levodopa)
Antagonistic effects, potentially reducing the efficacy of dopamine agonists.
CNS depressants (alcohol, barbiturates, opioids)
Increased sedation and central nervous system depression.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach and sight of children.
Overdose
Symptoms of overdose include somnolence, coma, extrapyramidal symptoms, convulsions, hypotension, shock, hyper/hypothermia. Treatment is supportive and symptomatic, including gastric lavage, activated charcoal, and monitoring vital signs and ECG.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Side Effects
Contraindications
- Acute alcohol, barbiturate or opioid intoxication
- Circulatory collapse
- Depressed level of consciousness
- Severe central nervous system (CNS) depression
- Phaeochromocytoma
- Bone marrow depression
- Blood dyscrasias
- Hypersensitivity to flupentixol or other thioxanthenes
Drug Interactions
Antihypertensives
Potentiates the hypotensive effect, leading to orthostatic hypotension.
Anticholinergic drugs
Potentiation of anticholinergic effects.
Drugs that prolong QT interval
Increased risk of QT prolongation and ventricular arrhythmias.
Dopamine agonists (e.g., levodopa)
Antagonistic effects, potentially reducing the efficacy of dopamine agonists.
CNS depressants (alcohol, barbiturates, opioids)
Increased sedation and central nervous system depression.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach and sight of children.
Overdose
Symptoms of overdose include somnolence, coma, extrapyramidal symptoms, convulsions, hypotension, shock, hyper/hypothermia. Treatment is supportive and symptomatic, including gastric lavage, activated charcoal, and monitoring vital signs and ECG.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from the manufacturing date, consult product packaging for exact date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., DGDA, EMA)
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Flupentixol has been extensively studied in clinical trials demonstrating its efficacy and safety in various psychiatric conditions including schizophrenia, depression with anxiety, and chronic anxiety. Ongoing research focuses on long-term effects and comparative effectiveness.
Lab Monitoring
- Complete Blood Count (CBC)
- Liver Function Tests (LFTs)
- Renal Function Tests (RFTs)
- ECG (especially at higher doses or with cardiac risk factors)
- Blood glucose and lipid profile (for metabolic changes)
Doctor Notes
- Monitor patients for extrapyramidal symptoms, particularly during the initiation of therapy and dose adjustments.
- Regularly assess for QTc prolongation, especially in patients with pre-existing cardiac conditions or those on concomitant medications that prolong the QT interval.
- Educate patients and caregivers on the importance of adherence, potential side effects, and warning signs of serious adverse events like Neuroleptic Malignant Syndrome.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Do not stop taking Precodil suddenly without consulting your doctor, as it can lead to withdrawal symptoms or relapse.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Report any unusual or severe side effects immediately to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not take a double dose to compensate for a missed one.
Driving Precautions
Precodil may cause drowsiness, dizziness, or blurred vision. Patients should be warned about engaging in activities that require mental alertness, such as driving or operating machinery, until they know how the drug affects them.
Lifestyle Advice
- Avoid driving or operating heavy machinery until you are certain how this medicine affects your alertness and coordination.
- Avoid alcohol consumption while on this medication.
- Maintain regular follow-up appointments with your doctor to monitor your progress and manage any side effects.
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